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Titolo:
EXPRESSION OF INTEGRIN ALPHA-V-BETA-3 IN SMALL BLOOD-VESSELS OF GLIOBLASTOMA TUMORS
Autore:
GLADSON CL;
Indirizzi:
UNIV ALABAMA,DEPT PATHOL,DIV NEUROPATHOL,LHRB 567,701 S 19TH ST BIRMINGHAM AL 35294
Titolo Testata:
Journal of neuropathology and experimental neurology
fascicolo: 11, volume: 55, anno: 1996,
pagine: 1143 - 1149
SICI:
0022-3069(1996)55:11<1143:EOIAIS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; MICROVASCULAR ENDOTHELIAL-CELLS; AMINO-ACID SEQUENCE; HUMAN-BRAIN TUMORS; VITRONECTIN RECEPTOR; ANGIOGENESIS; ADHESION; ALPHA(V)BETA(3); PROTEIN; MULTIFORME;
Keywords:
ADHESION; ANGIOGENESIS; GLIOBLASTOMA; INTEGRIN RECEPTOR ALPHA-V-BETA-3; INTEGRIN RECEPTOR ALPHA-V-BETA-5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
C.L. Gladson, "EXPRESSION OF INTEGRIN ALPHA-V-BETA-3 IN SMALL BLOOD-VESSELS OF GLIOBLASTOMA TUMORS", Journal of neuropathology and experimental neurology, 55(11), 1996, pp. 1143-1149

Abstract

Angiogenesis, which promotes tumor proliferation and invasiveness, ismediated by integrin-dependent cell adhesion mechanisms and requires expression of integrin alpha v beta 3. To determine whether integrin alpha v beta 3 is expressed in the small blood vessel hyperplasia characteristic of glioblastoma tumors, we explored the mRNA and protein expression of integrin alpha v, beta 3, beta 5, and beta 1 subunits in small blood vessels in gliomas of various grades and nontumorous brain biopsies. Antisense beta 3 and beta 5 riboprobes hybridized to small blood vessels (endothelial and adjacent mesenchymal cells) in 11 of 11 glioblastomas and 2 of 4 anaplastic astrocytomas, but failed to hybridize to small blood vessels in 12 non-neoplastic specimens and 4 low-grade astrocytomas. In contrast, antisense alpha v and beta 1 riboprobes hybridized to small blood vessels in all of the biopsies. The expression of integrin alpha v beta 3 protein in these vessels was determined by immunohistochemical analysis using anti-integrin subunit-specific antibodies. The findings were similar to those obtained using in situ hybridization: beta 3 subunit protein was detected on small blood vessels in 9 of 12 glioblastoma and 2 of 4 anaplastic astrocytomas, whereasit was not detected in small blood vessels of 10 non-neoplastic brains and 4 low-grade astrocytomas. In contrast, the alpha v and beta 1 subunit proteins were detected in small blood vessels in all of the brain biopsies, whereas the beta 5 subunit protein could not be detected. These data suggest that integrin alpha v beta 3 is expressed in small blood vessels of glioblastoma rumors.

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Documento generato il 02/12/20 alle ore 05:33:24