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Titolo:
CHRONIC VIRAL-HEPATITIS INDUCED BY HEPATITIS-C BUT NOT HEPATITIS-B VIRUS-INFECTION CORRELATES WITH INCREASED LIVER ANGIOGENESIS
Autore:
MAZZANTI R; MESSERINI L; MONSACCHI L; BUZZELLI G; ZIGNEGO AL; FOSCHI M; MONTI M; LAFFI G; MORBIDELLI L; FANTAPPIE O; OMER FBS; ZICHE M;
Indirizzi:
UNIV FLORENCE,INST INTERNAL MED,VIALE MORGAGNI 85 FLORENCE ITALY UNIV FLORENCE,INST PATHOL ANAT FLORENCE ITALY UNIV FLORENCE,DEPT PHARMACOL FLORENCE ITALY
Titolo Testata:
Hepatology
fascicolo: 1, volume: 25, anno: 1997,
pagine: 229 - 234
SICI:
0270-9139(1997)25:1<229:CVIBHB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCELLULAR-CARCINOMA; ENDOTHELIAL-CELLS; RISK FACTOR; CIRRHOSIS; ADHESION; DISEASE; CANCER; REPLICATION; EXPRESSION; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
R. Mazzanti et al., "CHRONIC VIRAL-HEPATITIS INDUCED BY HEPATITIS-C BUT NOT HEPATITIS-B VIRUS-INFECTION CORRELATES WITH INCREASED LIVER ANGIOGENESIS", Hepatology, 25(1), 1997, pp. 229-234

Abstract

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections lead to cirrhosis and increase the risk for the development of hepatocellular carcinoma (HCC). Angiogenesis is an essential step in oncogenesis and contributes to tumor progression in adult organs; however, to what extent angiogenesis occurs in the liver during chronic viral hepatitis has not been studied. Ninety-nine matched patients affected bychronic hepatitis due to either HBV or HCV were studied together with13 controls (5 patients were affected by familial hyperbilirubinemia with normal liver histology; 6 patients with stage II primary biliary cirrhosis; and 2 patients with pseudo inflammatory tumor). Microvesseldensity was assessed in liver biopsies by immunostaining using two different antibodies against endothelial cell antigens, QB-END/10 and Factor VIII. In addition, the liver homogenates and sera of HCV- or HBV-positive patients and controls were tested for their capacity to stimulate the migration and proliferation of freshly isolated human endothelial cells in vitro. Evidence of angiogenesis was significantly more frequent in HCV-positive patients compared with HBV-infected subjects or controls (74% vs. 39% vs. 8%) (chi(2) = 20.78; P <.0001) (HCV+ vs. HBV+ vs. controls). The degree of microvessel density was also higher in HCV- than in HBV-positive patients or controls (chi(2) - 12.28; P <.005). In addition, HCV-positive sera and liver homogenates stimulated a higher migration and proliferation of human endothelial cells in vitro compared with HBV-positive or control sera and liver homogenates. These observations indicate that angiogenesis is particularly linked toHCV infection, suggesting a possible contribution to HCV-related Liver oncogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:34:35