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Titolo:
EVALUATION OF INTERLEUKIN-10 AND INTERFERON-ALPHA IN THE CEREBROSPINAL-FLUID AND SERUM OF PATIENTS WITH MULTIPLE-SCLEROSIS
Autore:
CARRIERI PB; MAIORINO A; PROVITERA V; PERRELLA A; PERRELLA O;
Indirizzi:
VIA E A MANO 35 I-80131 NAPLES ITALY UNIV NAPLES FEDERICO II,SCH MED 2,DEPT NEUROL NAPLES ITALY D COTUGNO HOSP INFECT DIS NAPLES ITALY
Titolo Testata:
European journal of neurology
fascicolo: 6, volume: 3, anno: 1996,
pagine: 544 - 547
SICI:
1351-5101(1996)3:6<544:EOIAII>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; RECEPTOR;
Keywords:
CEREBROSPINAL FLUID; INTERLEUKIN-10; INTERFERON-ALPHA; MULTIPLE SCLEROSIS; INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
P.B. Carrieri et al., "EVALUATION OF INTERLEUKIN-10 AND INTERFERON-ALPHA IN THE CEREBROSPINAL-FLUID AND SERUM OF PATIENTS WITH MULTIPLE-SCLEROSIS", European journal of neurology, 3(6), 1996, pp. 544-547

Abstract

The activities of IL-10, a cytokine produced by TH2 cells, monocytes and B-cells, and IFN-alpha, a product of activated macrophages/monocytes, were investigated in the CSF and serum samples of 25 subjects withclinically definite multiple sclerosis (MS), of whom 14 were in the active and nine in the stable phase, and of 15 controls with other noninflammatory neurological diseases (OND). Elevated CSF IL-10 and IFN-alpha levels were found in MS patients in the stable phase with respect to patients in the active phase (p < 0.001), while no significant differences were observed in the mean serum levels between IL-10 patients (both in the active and stable phase) and controls. Finally, a significant correlation was detected between IL-10 and IFN-alpha in the CSP of MS patients in remission. This study suggests that IL-10 may downregulate MS progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:29:30