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Titolo:
APOE-EPSILON-4 IN AGE-RELATED MEMORY COMPLAINTS AND ALZHEIMERS-DISEASE
Autore:
TREVES TA; CHAPMAN J; BORNSTEIN NM; VERCHOVSKY R; ASHEROV A; VESHCHEV IO; KLIMOVITZKI S; KORCZYN AD;
Indirizzi:
TEL AVIV MED CTR & SCH MED,ICHILOV HOSP,DEPT NEUROL,6 WEIZMAN ST IL-64239 TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED,TEL AVIV MED CTR,DEPT NEUROL IL-69978 TEL AVIV ISRAEL
Titolo Testata:
European journal of neurology
fascicolo: 6, volume: 3, anno: 1996,
pagine: 515 - 518
SICI:
1351-5101(1996)3:6<515:AIAMCA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E EPSILON-4; LATE-ONSET; E ALLELE; ASSOCIATION; IMPAIRMENT; DEMENTIA;
Keywords:
APOE-EPSILON-4; APOLIPOPROTEIN E; AGE-ASSOCIATED MEMORY DISORDERS; ALZHEIMERS DISEASE; DEMENTIA; EPIDEMIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Treves et al., "APOE-EPSILON-4 IN AGE-RELATED MEMORY COMPLAINTS AND ALZHEIMERS-DISEASE", European journal of neurology, 3(6), 1996, pp. 515-518

Abstract

APOE-epsilon 4 has been consistently found to be frequent in patientswith senile dementia of the Alzheimer type (SDAT), Since forgetfulness may represent an early stage of dementia, APOE-epsilon 4 frequency can be expected to be high in such subjects, particularly in those who later develop dementia. We examined here the proportion of epsilon 4 alleles in patients with SDAT (n = 179), controls (n = 154) and subjects with age-related memory complaints (ARMC, n = 167); 16 of them developed dementia of Alzheimer type and three of them dementia of vasculartype. We also evaluated the relative risk of dementia (of Alzheimer type) in ARMC subjects who are epsilon 4-carriers, using a Cox proportional hazards model. The APOE-epsilon 4 allele frequency was 27% in SDAT, 25% in ARMC patients who became demented, 15% in ARMC subjects who remained such after at least 1 year of follow-up, and 10% in controls. APOE-epsilon 4 allele was significantly more frequent in SDAT than incontrols or than in stable ARMC (OR = 3.7 [2-6.3] and OR = 2.5 [1.5-4], respectively, p < 0.01). The risk of dementia in ARMC subjects carrying an epsilon 4 allele was three-fold that of those without (exp beta = 3.1 [0.98-10], p = 0.05). Older age at onset of memory decline andlower minimental scores at initial visit were also associated with development of dementia in ARMC subjects (exp beta = 1.1 [1.0-1.2], p = 0.05 and exp = 0.76 [0.6-0.9]), p = 0.008). In conclusion, the APOE-epsilon 4 allele was found to occur frequently in ARMC who subsequently develop dementia, therefore it can indicate a predisposition for dementia in such patients.

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Documento generato il 30/09/20 alle ore 22:51:37