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Titolo:
INVOLVEMENT OF CODEINE IN DRUG-RELATED DEATHS
Autore:
GEROSTAMOULOS J; BURKE MP; DRUMMER OH;
Indirizzi:
MONASH UNIV,VICTORIAN INST FORENS MED,DEPT FORENS MED,57-83 KAVANAGH ST SOUTHBANK VIC 3006 AUSTRALIA MONASH UNIV,VICTORIAN INST FORENS MED,DEPT FORENS MED SOUTHBANK VIC 3006 AUSTRALIA
Titolo Testata:
The American journal of forensic medicine and pathology
fascicolo: 4, volume: 17, anno: 1996,
pagine: 327 - 335
SICI:
0195-7910(1996)17:4<327:IOCIDD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORENSIC TOXICOLOGY; MORPHINE; BLOOD; CHROMATOGRAPHY; SCREEN;
Keywords:
CODEINE; TOXICITY; INCIDENCE; AUTOPSY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J. Gerostamoulos et al., "INVOLVEMENT OF CODEINE IN DRUG-RELATED DEATHS", The American journal of forensic medicine and pathology, 17(4), 1996, pp. 327-335

Abstract

The incidence and role of codeine in drug-related deaths in Victoria was investigated over a 5-year period. There were a total of 107 casesinvolving codeine, representing 8.8% of all drug-related deaths in this period in Victoria. There were only six fatalities in which codeinewas considered the major poison. The mean (+/-SD) concentration of codeine in femoral blood was 4.0+/-2.3 mg/L (range, 2.1-8.0 mg/L). The mean concentration of free codeine was 1.3+/-0.9 mg/L (range, 0.4-2.8 mg/L). The remaining 101 cases involved a combination of codeine and other drugs. The mean total codeine blood concentration was 1.8+/-3.3 mg/L (range, 0.04-26 mg/L), which was significantly lower than in those cases where codeine was the major poison (p <0.002). The mean concentration of free codeine was 0.82+/-4.9 mg/L (range, 0.02-9.0 mg/L), which was not significantly different (p >0.05) from the six codeine-only cases. The most common drugs found in this group, other than codeine, were acetaminophen (62%), diazepam (46%), salicylate (20%), and ethanol (25%). The association of other psychoactive drugs in these deaths made the contribution of codeine difficult to assess. Free codeine concentrations >0.4 mg/L and total codeine concentrations >2.0 mg/L may besufficient to cause death in the absence of any other contributing factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:58:06