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Titolo:
AMMONIUM TRANSPORT AND THE ROLE OF THE NA,K-ATPASE
Autore:
WALL SM;
Indirizzi:
UNIV TEXAS,SCH MED,DIV RENAL DIS & HYPERTENS,6431 FANNIN,MSB 4 148 HOUSTON TX 77030
Titolo Testata:
Mineral and electrolyte metabolism
fascicolo: 5-6, volume: 22, anno: 1996,
pagine: 311 - 317
SICI:
0378-0392(1996)22:5-6<311:ATATRO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
THICK ASCENDING LIMB; MICROVILLUS MEMBRANE-VESICLES; CHRONIC RESPIRATORY-ACIDOSIS; PROXIMAL CONVOLUTED TUBULE; CHRONIC METABOLIC-ACIDOSIS; RAT INNER MEDULLA; NA+-H+ EXCHANGER; BICARBONATE TRANSPORT; NEPHRON SEGMENTS; BASOLATERAL MEMBRANE;
Keywords:
AMMONIA; AMMONIUM; NA,K-ATPASE; PROXIMAL TUBULE; LOOP OF HENLE; COLLECTING DUCT; ACIDIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Wall, "AMMONIUM TRANSPORT AND THE ROLE OF THE NA,K-ATPASE", Mineral and electrolyte metabolism, 22(5-6), 1996, pp. 311-317

Abstract

Ammonium (NH4+) excretion varies appropriately with changes in acid-base balance and represents the major regulatable component of net acidexcretion. The transport of ammonium can occur by ''diffusion trapping'', or active H+ secretion in parallel with passive NH3 diffusion. Inaddition, direct NH4+ transport is important in many nephron segments. Since NH(4)( )and K+ have a similar hydrated radius, these ions share common transport pathways in many renal and nonrenal cell types. Forexample, these ions compete for a common binding site on the Na,K-ATPase. In addition to Na+ pump-mediated NH4+ transport, the Na,K-ATPase generates an electrochemical gradient across the cell membrane which affects other H+ and NH4+ transport pathways. In this review, the role of the Na+ pump on each of these renal ammonium transport mechanisms will be reviewed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:20:06