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Titolo:
GAMMA-KNIFE FOR GLIOMA - SELECTION FACTORS AND SURVIVAL
Autore:
LARSON DA; GUTIN PH; MCDERMOTT M; LAMBORN K; SNEED PK; WARA WM; FLICKINGER JC; KONDZIOLKA D; LUNSFORD LD; HUDGINS WR; FRIEHS GM; HASELSBERGER K; LEBER K; PENDL G; CHUNG SS; COFFEY RJ; DINAPOLI R; SHAW EG; VERMEULEN S; YOUNG RF; HIRATO M; INOUE HK; OHYE C; SHIBAZAKI T;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT RADIAT ONCOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT NEUROL SURG SAN FRANCISCO CA 94143 UNIV PITTSBURGH,MED CTR,DEPT RADIAT ONCOL PITTSBURGH PA 00000 UNIV PITTSBURGH,MED CTR,DEPT NEUROL SURG PITTSBURGH PA 00000 PRESBYTERIAN MED CTR,DEPT NEUROL SURG DALLAS TX 00000 KARL FRANZENS UNIV GRAZ,DEPT NEUROL SURG GRAZ AUSTRIA YONSEI UNIV,COLL MED,DEPT NEUROL SURG SEOUL 120749 SOUTH KOREA MAYO CLIN,DEPT NEUROL SURG ROCHESTER MN 00000 MAYO CLIN,DEPT NEUROL ROCHESTER MN 00000 MAYO CLIN,DEPT RADIAT ONCOL ROCHESTER MN 00000 NW HOSP,DEPT RADIAT ONCOL SEATTLE WA 00000 NW HOSP,DEPT NEUROL SURG SEATTLE WA 00000 GUNMA UNIV,SCH MED,DEPT NEUROL SURG MAEBASHI GUMMA 371 JAPAN HIDAKA HOSP,DEPT NEUROL SURG TAKASAKI GUMMA JAPAN
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 5, volume: 36, anno: 1996,
pagine: 1045 - 1053
SICI:
0360-3016(1996)36:5<1045:GFG-SF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEREOTAXIC RADIOSURGERY; GLIOBLASTOMA-MULTIFORME; BRACHYTHERAPY; RADIOTHERAPY; RESECTION; THERAPY; BIOPSY;
Keywords:
BRACHYTHERAPY; BRAIN NEOPLASM; COMPLICATIONS; GAMMA KNIFE; MALIGNANT GLIOMA; RADIOSURGERY; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Larson et al., "GAMMA-KNIFE FOR GLIOMA - SELECTION FACTORS AND SURVIVAL", International journal of radiation oncology, biology, physics, 36(5), 1996, pp. 1045-1053

Abstract

Purpose: To determine factors associated with survival differences inpatients treated with radiosurgery for glioma. Methods and Materials:We analyzed 189 patients treated with Gamma Knife radiosurgery for primary or recurrent glioma World Health Organization (WHO) Grades 1-4. Results: The median minimum tumor dose was 16 Gy (8-30 Gy) and the median tumor volume was 5.9 cc (1.3-52 cc). Brachytherapy selection criteria were satisfied in 65% of patients. Median follow-up of all surviving patients was 65 weeks after radiosurgery. For primary glioblastoma patients, median survival from the date of pathologic diagnosis was 86weeks if brachytherapy criteria were satisfied and 40 weeks if they were not (p = 0.01), indicating that selection factors strongly influence survival. Multivariate analysis showed that increased survival was associated with five variables: lower pathologic grade, younger age, increased Karnofsky performance status (KPS), smaller tumor volume, andunifocal tumor. Survival was not found to be significantly related toradiosurgical technical parameters (dose, number of isocenters, prescription isodose percent, inhomogeneity) or extent of preradiosurgery surgery. We developed a hazard ratio model that is independent of the technical details of radiosurgery and applied it to reported radiosurgery and brachytherapy series, demonstrating a significant correlation between survival and hazard ratio. Conclusions: Survival after radiosurgery for glioma is strongly related to five selection variables. Much of the variation in survival reported in previous series can be attributed to differences in distributions of these variables. These variables should be considered in selecting patients for radiosurgery and in the design of future studies. Copyright (C) 1996 Elsevier Science Inc.

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Documento generato il 02/07/20 alle ore 22:08:16