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Titolo:
CD2 SIGNALING IN T-CELLS INVOLVES TYROSINE PHOSPHORYLATION AND ACTIVATION OF THE TEC FAMILY KINASE, EMT ITK/TSK/
Autore:
KING PD; SADRA A; HAN A; LIU JR; SUNDERPLASSMANN R; REINHERZ EL; DUPONT B;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,PROGRAM IMMUNOL,1275 YORK AVE NEW YORK NY 10021 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,IMMUNOBIOL LAB BOSTON MA 02115
Titolo Testata:
International immunology
fascicolo: 11, volume: 8, anno: 1996,
pagine: 1707 - 1714
SICI:
0953-8178(1996)8:11<1707:CSITIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-LINKED AGAMMAGLOBULINEMIA; FUNCTION-ASSOCIATED ANTIGEN-3; NATURAL-KILLER-CELLS; LYMPHOCYTE-T; ERYTHROCYTE RECEPTOR; CYTOPLASMIC DOMAIN; BRUTON TYROSINE; SURFACE LIGAND; BINDING-SITE; SRC FAMILY;
Keywords:
COSTIMULATORY MOLECULES; PROTEIN KINASES; SIGNAL TRANSDUCTION; T LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
P.D. King et al., "CD2 SIGNALING IN T-CELLS INVOLVES TYROSINE PHOSPHORYLATION AND ACTIVATION OF THE TEC FAMILY KINASE, EMT ITK/TSK/", International immunology, 8(11), 1996, pp. 1707-1714

Abstract

Ligation of the CD2 cell surface glycoprotein expressed on T lymphocytes and NK cells induces protein tyrosine phosphorylation and activation of the Src kinases, LCK and FYN. We show here that in Jurkat T leukemia cells and in peripheral blood T cells, CD2 stimulation also leadsto tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK. Activation of EMT by CD2 was induced by mitogenic pairs of CD2 mAb, certain single CD2 mAb followed by secondary antibody cross-linking, and CD58-bearing sheep red blood cells. With the use of different Jurkat cell mutants it was demonstrated that CD2-mediated activation of EMT required expression of LCK, but did not require surface expression of the CD3 zeta chain. Receptor-mediated activation of LCK does not in itself lead to activation of this Tec kinase since inductionof LCK by ligation of CD4 or CD5 did not result in activation of EMT. The activation of EMT during CD2 signaling suggests an important rolefor this kinase in CD2 co-stimulation of T cell responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:22:58