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Titolo:
AMITRIPTYLINE, A COMBINED SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR, REDUCES EXTEROCEPTIVE SUPPRESSION OF TEMPORAL MUSCLE-ACTIVITY IN PATIENTS WITH CHRONIC TENSION-TYPE HEADACHE
Autore:
BENDTSEN L; JENSEN R; OLESEN J;
Indirizzi:
UNIV COPENHAGEN,GLOSTRUP HOSP,DEPT NEUROL DK-2600 GLOSTRUP DENMARK
Titolo Testata:
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
fascicolo: 5, volume: 101, anno: 1996,
pagine: 418 - 422
SICI:
0924-980X(1996)101:5<418:AACSAN>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOOTH-PULP STIMULATION; EXPERIMENTAL PAIN; MASSETER; REFLEX; MIGRAINE; PERIODS; BLIND;
Keywords:
AMITRIPTYLINE; EXTEROCEPTIVE SUPPRESSION; SEROTONIN; SILENT PERIOD; TENSION-TYPE HEADACHE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
L. Bendtsen et al., "AMITRIPTYLINE, A COMBINED SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR, REDUCES EXTEROCEPTIVE SUPPRESSION OF TEMPORAL MUSCLE-ACTIVITY IN PATIENTS WITH CHRONIC TENSION-TYPE HEADACHE", ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 101(5), 1996, pp. 418-422

Abstract

Although reflexes in human jaw muscles have been extensively studied,the neurotransmitters involved in the regulation of these reflexes are not well known. The aim of the present study was to investigate whether amitriptyline, a combined serotonin and noradrenaline re-uptake inhibitor, modulates the late exteroceptive suppression period (ES(2)) of temporal muscle activity in chronic tension-type headache. ES(2) wasrecorded with a previously evaluated method and assessed by a blindedobserver in 35 patients with chronic tension-type headache. Thereafter, ES(2) was recorded in 27 of these patients during a double-blind, placebo-controlled, 3-way crossover trial investigating the prophylactic effect of amitriptyline, the selective serotonin re-uptake inhibitorcitalopram, and placebo. ES(2) duration was significantly shorter during treatment with amitriptyline than during placebo, P = 0.02, while ES(2) duration only tended to be shorter during treatment with citalopram, P = 0.34. ES(2) was not significantly correlated to the prophylactic effect of amitriptyline or to a range of clinical and experimentalpain parameters. Our results demonstrate that amitriptyline reduces ES(2) and indicate that ES(2) is modulated by serotonergic as well as noradrenergic neuronal pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:22:30