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Titolo:
IN-VIVO LOCALIZED NMR PROTON SPECTROSCOPY OF NORMAL APPEARING WHITE-MATTER IN PATIENTS WITH MULTIPLE-SCLEROSIS
Autore:
TOURBAH A; STIEVENART JL; IBAZIZEN MT; ZANNOLI G; LYONCAEN O; CABANIS EA;
Indirizzi:
CTR HOSP NATL OPHTALMOL XVXX,SERV NEURORADIOL PARIS FRANCE HOP LA PITIE SALPETRIERE,FEDERAT NEUROL PARIS FRANCE HOP BEAUJON,SERV BIOPHYS & MED NUCL CLICHY FRANCE GEN ELECT MED SYST BUC FRANCE
Titolo Testata:
Journal of neuroradiology
fascicolo: 2, volume: 23, anno: 1996,
pagine: 49 - 55
SICI:
0150-9861(1996)23:2<49:ILNPSO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; ACUTE OPTIC NEURITIS; L-ASPARTIC ACID; HUMAN-BRAIN; METABOLIC CHARACTERIZATION; RAT-BRAIN; IN-VIVO; INVIVO; RELAXATION; LESIONS;
Keywords:
PROTON MAGNETIC RESONANCE SPECTROSCOPY; NORMAL APPEARING WHITE MATTER; MULTIPLE SCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
A. Tourbah et al., "IN-VIVO LOCALIZED NMR PROTON SPECTROSCOPY OF NORMAL APPEARING WHITE-MATTER IN PATIENTS WITH MULTIPLE-SCLEROSIS", Journal of neuroradiology, 23(2), 1996, pp. 49-55

Abstract

We used a rapid long TE proton magnetic resonance spectroscopic (MRS)sequence in the normal appearing white matter of 11 patients with definite multiple sclerosis (MS) localizing the volume of interest in thecentrum semi-ovale. The metabolic changes were compared to the same area in 11 normal brains. We found a significant decrease in NAA/Cr ratios and a borderline significance of increase in Cho/Cr ratios in patients with MS. A discriminant analysis was performed on these data. This allowed to obtain a simple ratio, NAA/(Cho + Myo), which discriminated MS patients from controls. Our results indicate that normal appearing white matter on MRT is biochemically abnormal in patients with MS. In addition MRS could be routinely used after a standard MRI examination in patients with MS for clinical correlations, total load of the disease assessment and monitoring clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:36:15