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Titolo:
THE CYP2D6B ALLELE IS NOT OVERREPRESENTED IN A POPULATION OF GERMAN PATIENTS WITH IDIOPATHIC PARKINSONS-DISEASE
Autore:
GASSER T; MULLERMYHSOK B; SUPALA A; ZIMMER E; WIEDITZ G; WSZOLEK ZK; VIEREGGE P; BONIFATI V; OERTEL WH;
Indirizzi:
UNIV MUNICH,KLINIKUM GROSSHADERN,NEUROL KLIN,MARCHIONINISTR 15 D-81377 MUNICH GERMANY BERNHARD NOCHT INST TROP MED HAMBURG GERMANY TECH UNIV MUNICH,PSYCHIAT KLIN D-8000 MUNICH GERMANY PARACELSUS ELENA KLIN KASSEL GERMANY UNIV NEBRASKA,MED CTR,DEPT INTERNAL MED,NEUROL SECT OMAHA NE 68182 UNIV LUBECK,NEUROL KLIN D-2400 LUBECK GERMANY UNIV ROMA LA SAPIENZA,DIPARTIMENTO SCI NEUROL ROME ITALY UNIV MARBURG,NEUROL KLIN MARBURG GERMANY
Titolo Testata:
Journal of Neurology, Neurosurgery and Psychiatry
fascicolo: 5, volume: 61, anno: 1996,
pagine: 518 - 520
SICI:
0022-3050(1996)61:5<518:TCAINO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYLASE GENE POLYMORPHISM; ASSOCIATION;
Keywords:
IDIOPATHIC PARKINSONS DISEASE; DEBRISOQUINE 4-HYDROXYLASE; ALLELIC ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
T. Gasser et al., "THE CYP2D6B ALLELE IS NOT OVERREPRESENTED IN A POPULATION OF GERMAN PATIENTS WITH IDIOPATHIC PARKINSONS-DISEASE", Journal of Neurology, Neurosurgery and Psychiatry, 61(5), 1996, pp. 518-520

Abstract

The frequency of the CYP2D6B allele of the gene for debrisoquine 4-hydroxylase was studied in 115 patients with sporadic idiopathic Parkinson's disease, 55 of their healthy siblings, 63 patients with familial Parkinson's disease, 55 unaffected relatives, and 92 patients with Alzheimer's disease and 73 age matched healthy controls. By contrast withseveral previous studies, no significant variation of allele frequencies could be found between any of the groups studied. The results argue against a significant role of the CYP2D6 gene in the aetiology of sporadic and familial idiopathic parkinsonism in this patient population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:40:52