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Titolo:
VITAMIN-E METABOLISM OF THE LUNG
Autore:
TOLLE A; KOLLECK I; GUTHMANN F; RUSTOW B;
Indirizzi:
HUMBOLDT UNIV BERLIN,FAK MED,KLINIKUM CHARITE,KLIN & POLIKLIN KINDERHEILKUNDE,ABT NEONATOL D-10098 BERLIN GERMANY
Titolo Testata:
Fett
fascicolo: 10, volume: 98, anno: 1996,
pagine: 328 - 331
SICI:
0931-5985(1996)98:10<328:VMOTL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
GER
Soggetto:
II PNEUMOCYTES; FREE-RADICALS; SURFACTANT; PHOSPHATIDYLGLYCEROL; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
A. Tolle et al., "VITAMIN-E METABOLISM OF THE LUNG", Fett, 98(10), 1996, pp. 328-331

Abstract

Experimental and clinical data have provided evidence for the involvement of oxygen free radicals in the development of acute and chronic lung diseases. Alveolar surfactant is the prime target of oxidative airpollutants. Lung surfactant consists to 90% of lipids and contains vitamin E as most important lipophilic antioxidant. Recently, we showed that alveolar surfactant is supplemented with vitamin E during its synthesis in type II pneumocytes. Hyperoxia is very often a necessary therapeutic intervention which seems to impose oxidative stress on lung tissue. Hyperoxia caused an increase in vitamin E turnover, measured intype II pneumocytes, lamellar bodies and lung lavages. In contrast, the turnover of surfactant cholesterol and surfactant lipids does not change. Hyperoxia caused an increase in vitamin E uptake by type II pneumocytes and an enrichment of vitamin E in lamellar bodies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 14:54:18