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Titolo:
EXPERIMENTAL RHINOVIRUS INFECTION IN VOLUNTEERS
Autore:
BARDIN PG; SANDERSON G; ROBINSON BS; HOLGATE ST; TYRRELL DAJ;
Indirizzi:
UNIV STELLENBOSCH,DEPT INTERNAL MED,STELLENBOSCH UNIV PULM UNIT RES,POB 19063 ZA-7505 TYGERBERG SOUTH AFRICA UNIV MED SOUTHAMPTON,SOUTHAMPTON GEN HOSP,IMMUNOPHARMACOL GRP SOUTHAMPTON HANTS ENGLAND
Titolo Testata:
The European respiratory journal
fascicolo: 11, volume: 9, anno: 1996,
pagine: 2250 - 2255
SICI:
0903-1936(1996)9:11<2250:ERIIV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLDS; SYMPTOMS; ASTHMA;
Keywords:
COMMON COLD; INFECTIONS; RHINOVIRUS; VOLUNTEER STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
P.G. Bardin et al., "EXPERIMENTAL RHINOVIRUS INFECTION IN VOLUNTEERS", The European respiratory journal, 9(11), 1996, pp. 2250-2255

Abstract

Experimental viral disease studies in volunteers have clarified many aspects of the pathogenesis of human viral disease, Recently, interesthas focused on rhinovirus-associated asthma exacerbations, and new volunteer studies have suggested that airway responsiveness (AR) is enhanced during a cold, For scientific, ethical and safety reasons, it is important to use validated methods for the preparation of a virus inoculum and that the particular virological characteristics and host responses should not be altered, We have prepared a new human rhinovirus (HRV) inoculum using recent guidelines and assessed whether disease characteristics (for example, severity of colds or changes in AR) were retained. Studies were conducted in 25 clinically healthy volunteers using a validated HRV inoculum in the first 17 and a new inoculum in the subsequent eight subjects. Severity of cold symptoms, nasal wash albumin levels and airway responsiveness were measured, and the new inoculum was prepared from nasal washes obtained during the cold. The new inoculum was tested using standard virological and serological techniques, as well as a polymerase chain reaction for Mycoplasma pneumoniae. Nocontaminating viruses or organisms were detected and the methods suggested were workable, Good clinical colds developed in 20 of the 25 subjects and median symptom scores were similar in the validated and new inoculum groups (18 and 17.5, respectively; p=0.19). All subjects shedvirus, and there were no differences noted in viral culture scores, nasal wash albumin and rates of seroconversion in the two groups, Although airway responsiveness increased in both groups (p=0.02 and p=0.05), the degree of change was similar. We have performed experimental rhinovirus infection studies and demonstrated similar clinical disease intwo inoculum groups, Amplified airway responsiveness was induced; continuing studies will define the mechanisms and suggest modes of treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/10/20 alle ore 06:08:31