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Titolo:
THE USE OF -METHOXYMETHYL-16-BETA,17-BETA-EPIESTRIOL-O-CYCLIC SULFONEAS THE PRECURSOR IN THE SYNTHESIS OF F-18 16-ALPHA-FLUOROESTRADIOL
Autore:
LIM JL; ZHENG L; BERRIDGE MS; TEWSON TJ;
Indirizzi:
UNIV WASHINGTON,DEPT RADIOL,IMAGING RES LAB,BOX 356004 SEATTLE WA 98195 UNIV WASHINGTON,DEPT RADIOL,IMAGING RES LAB SEATTLE WA 98195 CASE WESTERN RESERVE UNIV,DEPT RADIOL CLEVELAND OH 44106 UNIV HOSP CLEVELAND CLEVELAND OH 44106
Titolo Testata:
Nuclear medicine and biology
fascicolo: 7, volume: 23, anno: 1996,
pagine: 911 - 915
SICI:
0969-8051(1996)23:7<911:TUO-S>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON TOMOGRAPHIC ASSESSMENT; ESTROGEN-RECEPTORS; BREAST-CANCER; FLUORIDE-ION; PET;
Keywords:
-METHOXYMETHYL-16-BETA,17-BETA-EPIESTRIOL-O-CYCLIC SULFONE; F-18 16-ALPHA-FLUOROESTRADIOL; CYCLIC SULFATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Lim et al., "THE USE OF -METHOXYMETHYL-16-BETA,17-BETA-EPIESTRIOL-O-CYCLIC SULFONEAS THE PRECURSOR IN THE SYNTHESIS OF F-18 16-ALPHA-FLUOROESTRADIOL", Nuclear medicine and biology, 23(7), 1996, pp. 911-915

Abstract

We have prepared 3-methoxymethyl-16 beta,17 beta-epiestriol-O-cyclic sulfone (1c) and used it as a substrate for the production of F-18 16 alpha-fluoroestradiol, via nucleophilic fluorination with fluoride ion. The compound is straightforward to make from the commercially available epiestriol and is a stable crystalline compound that can be storedfor at least a year at room temperature. Reaction with fluorine-18 fluoride provides excellent yields; typically >90% incorporation of the fluoride is achieved. Partial purification of the labeled product may be accomplished at this stage. Hydrolysis of the methoxymethyl protecting group and ring-opened sulfate occurs rapidly in ethanolic acid solution. In the presence of water the hydrolysis requires more vigorous conditions and additional time but still proceeds to completion. Labeled fluoroestradiol is isolated at the end of a 1-2 h synthesis, depending on the hydrolysis method of 30-45% chemical (decay corrected) yield with respect to fluoride, with a specific activity >1 Ci per micromole. Copyright (C) 1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:20:53