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Titolo:
SYNTHESIS AND PRELIMINARY EVALUATION OF (S)-(2-[F-18]FLUORO-4,5-DIHYDROXYPHENYL)-2-METHYL L-ALANINE, (S)-[F-18]-FMEDOPA, A POTENTIALLY IMPROVED IMAGING AGENT FOR THE PRESYNAPTIC DOPAMINERGIC NERVOUS-SYSTEM
Autore:
YOST Y; CONWAY T;
Indirizzi:
VET ADM MED CTR,PET IMAGING SERV,1 VET DR MINNEAPOLIS MN 55417 VET ADM MED CTR,PET IMAGING SERV MINNEAPOLIS MN 55417
Titolo Testata:
Nuclear medicine and biology
fascicolo: 7, volume: 23, anno: 1996,
pagine: 857 - 865
SICI:
0969-8051(1996)23:7<857:SAPEO(>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CATECHOL-O-METHYLTRANSFERASE; STRIATAL FLUORODOPA UPTAKE; LIVING HUMAN-BRAIN; F-18 DOPA UPTAKE; PARKINSONS-DISEASE; ALPHA-METHYLDOPA; METABOLISM; FLUORINATION; PROGRESSION;
Keywords:
PET IMAGING AGENT; DOPAMINERGIC NERVOUS SYSTEM; (2[F-18]FLUORO-4,5-DIHYDROXYPHENYL)-2-METHYL L-ALANINE; [F-18] FMEDOPA; [F-18] FDOPA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
Y. Yost e T. Conway, "SYNTHESIS AND PRELIMINARY EVALUATION OF (S)-(2-[F-18]FLUORO-4,5-DIHYDROXYPHENYL)-2-METHYL L-ALANINE, (S)-[F-18]-FMEDOPA, A POTENTIALLY IMPROVED IMAGING AGENT FOR THE PRESYNAPTIC DOPAMINERGIC NERVOUS-SYSTEM", Nuclear medicine and biology, 23(7), 1996, pp. 857-865

Abstract

The synthesis and preliminary rat biodistribution studies of (S)-(2-[F-18]fluoro-4,5-dihydroxyphenyl)-2-methyl L-alanine, (S)-[F-18]-FMEDOPA, a potentially improved imaging agent for the presynaptic dopaminergic nervous system, are reported. (S)-[F-18]-FMEDOPA produces a higher striatum-to-cerebellum (S/C) radioactivity ratio than the currently used PET imaging agent, (S)-[F-18]-FDOPA, does at 180 min after administration. Copyright (C) 1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:38:04