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Titolo:
REDUCTION OF GUINEA-PIG PUP ISOLATION CALLS BY ANXIOLYTIC AND ANTIDEPRESSANT DRUGS
Autore:
MOLEWIJK HE; HARTOG K; VANDERPOEL AM; MOS J; OLIVIER B;
Indirizzi:
SOLVAY DUPHAR BV,CNS PHARMACOL,POB 900 NL-1380 DA WEESP NETHERLANDS
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 128, anno: 1996,
pagine: 31 - 38
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT PUPS; BINDING-SITES; PHARMACOLOGICAL PROPERTIES; BEHAVIORAL-RESPONSES; MATERNAL SEPARATION; SPECIES-DIFFERENCES; 5-HT1A RECEPTORS; HIGH-AFFINITY; SEROTONIN; ANXIETY;
Keywords:
DISTRESS VOCALIZATIONS; GUINEA PIG PUP; ANXIOLYTICS; ANTIDEPRESSANTS; BENZODIAZEPINES; 5-HT1A RECEPTOR LIGANDS; 5-HT UPTAKE INHIBITORS; NA UPTAKE INHIBITOR; 5-CT 5-HT1D RECEPTOR; ALCOHOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
H.E. Molewijk et al., "REDUCTION OF GUINEA-PIG PUP ISOLATION CALLS BY ANXIOLYTIC AND ANTIDEPRESSANT DRUGS", Psychopharmacology, 128(1), 1996, pp. 31-38

Abstract

Guinea pigs possess central 5-HT1D receptors similar to humans but different from rats and mice. In order to study the role of this receptor on animal behaviour, it may be of interest to develop a paradigm measuring affective states in the guinea pig. Therefore we assessed the effects of a variety of psychotropic drugs on guinea pig pup isolation calls. Anxiolytic compounds such as the benzodiazepine receptor agonists diazepam and alprazolam, the full 5-HT1A receptor agonists 8-OH-DPAT and flesinoxan, and alcohol reduced isolation calling by the guinea pig pup. Moreover, mixed antidepressant/anxiolytic compounds like the 5-HT uptake inhibitors fluvoxamine and clomipramine or the MAO-inhibitor clorgyline as well as the antidepressant NA uptake inhibitors desipramine and maprotiline suppressed vocalizations. The 5-HT1D/1A receptor agonist 5-CT was also very effective in reducing separation calls. Remarkably, the partial 5-HT1A receptor agonists buspirone and BMY 7378did not affect calling. The neuroleptic haloperidol, the psychostimulant d-amphetamine, the putative anxiogenics DMCM and m-CPP and the putative anxiolytics ondansetron and CI-988 had no effect on isolation calls of guinea pig pups. We propose this paradigm could be helpful to assess behavioural effects of anxiolytic and antidepressant drugs in a species different from rat or mouse, and in which the effects of 5-HT1D receptor ligands may possibly be established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:44:58