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Titolo:
ANTIANGIOGENIC EFFECT OF LINOMIDE ON BREAST-CANCER VEGF TRANSFECTANTS
Autore:
ZICHE M; GASPARINI G; CHOUDHURI R; BICKNELL R; MORBIDELLI L; PARENTI A; LEDDA F;
Indirizzi:
UNIV FLORENCE,DEPT PHARMACOL,VIALE MORGAGNI 65 I-50134 FLORENCE ITALY SAN BORTOLO HOSP,DEPT ONCOL VICENZA ITALY UNIV OXFORD,INST MOL MED,IMPERIAL CANC RES FUND,MOL ANGIOGENESIS GRP OXFORD ENGLAND
Titolo Testata:
Oncology Reports
, volume: 4, anno: 1997, supplemento:, 1
pagine: 253 - 256
SICI:
1021-335X(1997)4:<253:AEOLOB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDEPENDENT PROGNOSTIC INDICATOR; ENDOTHELIAL-CELL GROWTH; RAT PROSTATIC CANCERS; TUMOR ANGIOGENESIS; QUINOLINE-3-CARBOXAMIDE LINOMIDE; T-CELL; CARCINOMA; IMMUNOMODULATOR; EXPRESSION; METASTASIS;
Keywords:
LINOMIDE; ANGIOGENESIS; VEGF; BREAST CARCINOMA; ENDOTHELIAL CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Ziche et al., "ANTIANGIOGENIC EFFECT OF LINOMIDE ON BREAST-CANCER VEGF TRANSFECTANTS", Oncology Reports, 4, 1997, pp. 253-256

Abstract

The effect of the quinoline-3-carboxiamide Linomide was studied on angiogenesis promoted by breast carcinoma cell populations overexpressing vascular endothelial growth factor (VEGF). Quantification of the antiangiogenic effect of Linomide was obtained by monitoring neovascular growth in the rabbit cornea assay. MCF-7 breast carcinoma cells stablytransfected with the cDNA encoding for VEGF(121) were used to elicit a potent VEGF-dependent corneal angiogenesis. The treatment of rabbitswith 100 mg/kg/day Linomide for 5 consecutive days produced a significant inhibition of angiogenesis. In vitro Linomide inhibited endothelial cell growth and migration elicited by VEGF, while the drug only partially modified endothelial cell growth induced by basic fibroblast growth factor (bFGF). We conclude that Linomide is an active drug able to inhibit VEGF dependent angiogenesis in breast carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:21:40