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Titolo:
CONTROL OF ARTERIOVENOUS ANASTOMOSES IN RABBIT EAR MODEL OF DIGITAL PERFUSION
Autore:
POLLOCK DC; LI ZY; KOMAN LA; GORDON ES; SMITH TL;
Indirizzi:
WAKE FOREST UNIV,MED CTR,DEPT ORTHOPAED SURG,MED CTR BLVD WINSTON SALEM NC 27157 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT ORTHOPAED SURG WINSTON SALEM NC 27157
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 5, volume: 40, anno: 1996,
pagine: 2007 - 2013
SICI:
0363-6135(1996)40:5<2007:COAAIR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROVASCULAR SMOOTH-MUSCLE; HUMAN FINGER SKIN; ALPHA-ADRENOCEPTORS; RAYNAUDS SYNDROME; VASOCONSTRICTION; CONTRACTION; TEMPERATURE; INNERVATION; VESSELS;
Keywords:
PHENYLEPHRINE; PRAZOSIN; TERAZOSIN; UK-14304; ATIPAMEZOLE; NOREPINEPHRINE; ALPHA-ADRENERGIC RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Pollock et al., "CONTROL OF ARTERIOVENOUS ANASTOMOSES IN RABBIT EAR MODEL OF DIGITAL PERFUSION", American journal of physiology. Heart and circulatory physiology, 40(5), 1996, pp. 2007-2013

Abstract

The arteriovenous anastomoses (AVA) of the cutaneous microcirculationof the hands and feet are fundamental determinants of thermoregulatory blood flow and may be involved in cold intolerance. These direct microvascular studies are an initial characterization of adrenergic receptor subtypes participating in control of AVA in the ears of anesthetized male New Zealand White rabbits. Adrenergic alpha(1)-stimulation with phenylephrine produced AVA constriction, whereas terazosin (an alpha(1)-antagonist) produced dilation and attenuated the responses to phenylephrine. Adrenergic alpha(2)-stimulation with UK-14304 produced constriction of the AVA, whereas atipamezole (an alpha(2)-antagonist) produced dilation and attenuated the responses to UK-14304. When equimolarconcentrations of antagonists were studied, the AVA dilation producedby alpha(2)-blockade was greater than that produced by alpha(1)-blockade. Norepinephrine (a mixed alpha(1)- and alpha(2)-agonist) also produced vasoconstriction, which was attenuated by both prazosin (an alpha(1)-antagonist) and atipamezole. In summary, 1) AVA contain a heterogeneous mixture of both aland alpha(2)-receptors, and 2) alpha(2)-receptors may have a greater influence than alpha(1)-receptors on overall tone in AVA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 07:07:00