Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ADHESION MOLECULE EXPRESSION BY EPIDERMAL LANGERHANS CELLS AND LYMPH-NODE DENDRITIC CELLS - A COMPARISON
Autore:
CUMBERBATCH M; DEARMAN RJ; KIMBER I;
Indirizzi:
ICI PLC,CENT TOXICOL LAB,ALDERLEY PK MACCLESFIELD SK10 4TJ CHESHIRE ENGLAND
Titolo Testata:
Archives of dermatological research
fascicolo: 12, volume: 288, anno: 1996,
pagine: 739 - 744
SICI:
0340-3696(1996)288:12<739:AMEBEL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; COLONY-STIMULATING FACTOR; CONTACT SENSITIZATION; FLUORESCEIN ISOTHIOCYANATE; COSTIMULATORY MOLECULE; ICAM-1 EXPRESSION; IMMUNE-RESPONSES; E-CADHERIN; ANTIGEN; MATURATION;
Keywords:
LANGERHANS CELL; DENDRITIC CELLS; INTERCELLULAR ADHESION MOLECULE-1; E-CADHERIN; CD44; CONTACT SENSITIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Cumberbatch et al., "ADHESION MOLECULE EXPRESSION BY EPIDERMAL LANGERHANS CELLS AND LYMPH-NODE DENDRITIC CELLS - A COMPARISON", Archives of dermatological research, 288(12), 1996, pp. 739-744

Abstract

The migration of epidermal Langerhans cells (LC) and their transport of antigen from the skin to draining lymph nodes are of considerable importance in the induction of cutaneous immune responses, including contact sensitization, While in transit to the lymph nodes, LC are subject to a number of phenotypic changes required for their movement from the skin and acquisition of the capacity for antigen presentation, Among these are alterations in the expression of adhesion molecules that regulate interactions with the surrounding tissue matrix and with T lymphocytes, In the study described here, we investigated, using a combination of immunocytochemistry and flow cytometry, the expression by LC, and the lymph node dendritic cells into which they mature, of the three adhesion molecules, E-cadherin, intercellular adhesion molecule-1 (ICAM-1) and the membrane glycoprotein CD44, The migration of LC was associated with a marked reduction in the expression of E-cadherin, buta parallel upregulation of ICAM-1, No change in the expression of CD44 was detectable, The significance of these changes and their relevance for the functional maturation of LC are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:34:14