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Titolo:
AN IN-VIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPY STUDY OF SCHIZOPHRENIA-PATIENTS
Autore:
STANLEY JA; WILLIAMSON PC; DROST DJ; RYLETT RJ; CARR TJ; MALLA A; THOMPSON RT;
Indirizzi:
UNIV WESTERN ONTARIO HOSP,DEPT PSYCHIAT,399 WINDERMERE RD,BOX 5339 LONDON ON N6A 5A5 CANADA UNIV PITTSBURGH,MED CTR,NEUROPHYSIOL LAB PITTSBURGH PA 00000 UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR LONDON ON N6A 4V2 CANADA
Titolo Testata:
Schizophrenia bulletin
fascicolo: 4, volume: 22, anno: 1996,
pagine: 597 - 609
SICI:
0586-7614(1996)22:4<597:AIPMSS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE PHOSPHOLIPID-METABOLISM; EXCITATORY AMINO-ACIDS; HUMAN-BRAIN INVIVO; PREFRONTAL CORTEX; IN-VIVO; NMR-SPECTROSCOPY; MACROMOLECULE RESONANCES; STIMULATED ECHOES; H-1-NMR SPECTRA; TEMPORAL LOBES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Stanley et al., "AN IN-VIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPY STUDY OF SCHIZOPHRENIA-PATIENTS", Schizophrenia bulletin, 22(4), 1996, pp. 597-609

Abstract

The level of the H-1 metabolites in the left dorsolateral prefrontal region of schizophrenia patients at different stages of illness were measured in vivo using a short echo time spectroscopy technique. Duringboth the early onset and chronic stages, normal N-acetylaspartate levels were observed, which suggests that these patients had no significant neuronal cell damage and/or toss. The in vivo measurements of glutamate in the first-episode, drug naive patients failed to provide convincing evidence for the involvement of the glutamatergic system in the dorsolateral prefrontal region. Significant differences in the glutamine levels were observed in the acutely medicated and chronic patients;however, the interpretation of these differences requires further study.

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Documento generato il 06/08/20 alle ore 23:32:46