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Titolo:
DIFFERENTIAL REGULATION OF INTERLEUKIN-12-INDUCED AND INTERLEUKIN-15-INDUCED NATURAL-KILLER-CELL ACTIVATION BY INTERLEUKIN-4
Autore:
SALVUCCI O; MAMICHOUAIB F; MOREAU JL; THEZE J; CHEHIMI J; CHOUAIB S;
Indirizzi:
INST GUSTAVE ROUSSY,INSERM,CJF 94 11,LAB CYTOKINES & IMMUN ANTITUMORALE F-94805 VILLEJUIF FRANCE INST GUSTAVE ROUSSY,INSERM,CJF 94 11,LAB CYTOKINES & IMMUN ANTITUMORALE F-94805 VILLEJUIF FRANCE INST PASTEUR,UNITE IMMUNOGENET CELLULAIRE PARIS FRANCE CHILDRENS HOSP PHILADELPHIA PHILADELPHIA PA 19104
Titolo Testata:
European Journal of Immunology
fascicolo: 11, volume: 26, anno: 1996,
pagine: 2736 - 2741
SICI:
0014-2980(1996)26:11<2736:DROIAI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE MATURATION FACTOR; STIMULATORY FACTOR NKSF; TUMOR-NECROSIS-FACTOR; IL-2 RECEPTOR; HETERODIMERIC CYTOKINE; INTERFERON-GAMMA; BETA-CHAIN; IFN-GAMMA; TNF-ALPHA; LYMPHOKINE;
Keywords:
INTERLEUKIN-4; INTERLEUKIN-12; INTERLEUKIN-15; NATURAL KILLER CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
O. Salvucci et al., "DIFFERENTIAL REGULATION OF INTERLEUKIN-12-INDUCED AND INTERLEUKIN-15-INDUCED NATURAL-KILLER-CELL ACTIVATION BY INTERLEUKIN-4", European Journal of Immunology, 26(11), 1996, pp. 2736-2741

Abstract

The regulation of human natural killer (NK) cell activation is under the control of a network of regulatory signals provided by cytokines. In the present study, we investigated the functional interaction between interleukin (IL)-4 and two monocyte/macrophage-derived cytokines, IL-12 and IL-15, during the process of NK stimulation. Using freshly isolated human NK cells, we have demonstrated that IL-4 negatively regulates lymphokine-activated killer (LAK) activity induced by IL-15 against the NK-resistant Daudi target cells. In contrast, IL-4 had no effect on IL-12-stimulated LAK generation. The differential effect of IL-4 on NK cell activation by IL-12 and IL-15 correlates with its ability to increase or to down-regulate the level of tumor necrosis factor-alpha and interferon-gamma release by NK cells, respectively. In contrast,endogenous transforming growth factor-beta 1 does not appear to be involved in the IL-4 regulatory pathway. Furthermore, while IL-4 was found to decrease the basal expression of the IL-2 receptor beta subunit utilized by IL-15, it had no effect on the expression of the beta 1 chain of the IL-12 receptor compared to untreated cells. Northern blot analysis indicated that the IL-4 regulatory effect on NK lytic functionwas associated with its capacity to down-regulate granzyme B and perforin gene transcription in response to IL-15 and its failure to affectthe expression of both gene's in response to IL-12. Together, these data suggest the existence of a distinct cross-talk between IL-4 and IL-15 or IL-12 signaling pathways during the regulation of human non-major histocompatibility complex-restricted cytotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:13:28