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Titolo:
IMMUNODOMINANCE OF CYTOTOXIC T-LYMPHOCYTE EPITOPES CO-INJECTED IN-VIVO AND MODULATION BY INTERLEUKIN-12
Autore:
EBERL G; KESSLER B; EBERL LP; BRUNDA MJ; VALMORI D; CORRADIN G;
Indirizzi:
UNIV LAUSANNE,INST BIOCHEM,CH DES BOVERESSES 155 CH-1066 EPALINGES SWITZERLAND UNIV LAUSANNE,INST BIOCHEM CH-1066 EPALINGES SWITZERLAND LUDWIG INST CANC RES,LAUSANNE BRANCH CH-1066 EPALINGES SWITZERLAND HOFFMANN LA ROCHE INC,DEPT ONCOL NUTLEY NJ 07110
Titolo Testata:
European Journal of Immunology
fascicolo: 11, volume: 26, anno: 1996,
pagine: 2709 - 2716
SICI:
0014-2980(1996)26:11<2709:IOCTEC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; SYNTHETIC PEPTIDES; ANTIGENIC PEPTIDES; CELL DETERMINANTS; INTERFERON-GAMMA; BINDING MOTIF; VIRUS TYPE-1; MICE; SELECTION; INFECTION;
Keywords:
CTL; IMMUNODOMINANCE; INTERLEUKIN-12; PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
G. Eberl et al., "IMMUNODOMINANCE OF CYTOTOXIC T-LYMPHOCYTE EPITOPES CO-INJECTED IN-VIVO AND MODULATION BY INTERLEUKIN-12", European Journal of Immunology, 26(11), 1996, pp. 2709-2716

Abstract

Immunodominance (ID) of T cell epitopes is a well-documented phenomenon that might have profound significance in the evolution of T cell responses to pathogens, tumors, autoantigens and vaccines. With the intention of developing vaccines composed of several cytotoxic T cell (CTL) epitopes, we injected mice with peptide mixtures containing two to five CTL epitopes and observed clear patterns of ID. In a first case, ID strictly correlated with the competitor activity of the individual peptides for H-2K(d), whereas in a second case, the absence of correlation between ID and competitor activity, binding affinity, half-life ofthe peptides in serum, induction of proliferation in vitro and the individual immunogenicity of the peptides, suggested to us that ID of co-injected CTL epitopes can be determined both at the peptide level (binding affinity to H-2K(d)) and at the T cell level. This hypothesis issupported by our finding that interleukin-12 strongly modulates ID when it is not correlated with MHC binding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:44:49