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Titolo:
DENDRITIC CELLS PROCESS EXOGENOUS VIRAL-PROTEINS AND VIRUS-LIKE PARTICLES FOR CLASS-I PRESENTATION TO CD8(-LYMPHOCYTES() CYTOTOXIC T)
Autore:
BACHMANN MF; LUTZ MB; LAYTON GT; HARRIS SJ; FEHR T; RESCIGNO M; RICCIARDICASTAGNOLI P;
Indirizzi:
CNR,CTR CELLULAR & MOL PHARMACOL,VIA VANVITELLI 32 I-20129 MILAN ITALY CNR,CTR CELLULAR & MOL PHARMACOL I-20129 MILAN ITALY UNIV ZURICH,INST EXPT IMMUNOL,DEPT PATHOL CH-8091 ZURICH SWITZERLAND BRITISH BIOTECH PHARMACEUT LTD OXFORD ENGLAND
Titolo Testata:
European Journal of Immunology
fascicolo: 11, volume: 26, anno: 1996,
pagine: 2595 - 2600
SICI:
0014-2980(1996)26:11<2595:DCPEVA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-PRESENTING CELLS; MINOR H-ANTIGENS; MHC MOLECULES; CROSS-REACT; INDUCTION; PATHWAY; IMMUNIZATION; PHAGOCYTOSIS; EXPRESSION; RESPONSES;
Keywords:
CYTOTOXIC T LYMPHOCYTE; ANTIGEN PRESENTATION; DENDRITIC CELL; EXOGENOUS ANTIGEN; VIRUS-LIKE PARTICLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Bachmann et al., "DENDRITIC CELLS PROCESS EXOGENOUS VIRAL-PROTEINS AND VIRUS-LIKE PARTICLES FOR CLASS-I PRESENTATION TO CD8(-LYMPHOCYTES() CYTOTOXIC T)", European Journal of Immunology, 26(11), 1996, pp. 2595-2600

Abstract

Previous reports have indicated that both dendritic cells and macrophages have the ability to induce cytotoxic T lymphocyte (CTL) and T helper (Th) cell responses in vivo. Dendritic cells process exogenous antigens conventionally for presentation on major histocompatibility complex (MHC) class II molecules. However, unconventional processing of exogenous antigens in vitro for presentation on MHC class I molecules isstill an open question. In this study, we report that a cloned dendritic cell line (D2SC/1) is able to present cell debris-associated exogenous viral proteins to MHC class I-restricted CTL in vitro. The dendritic cell line was very efficient in processing recombinant lymphocyticchoriomeningitis virus nucleoprotein (LCMV NP) and presenting the class I-restricted epitope to Cm primed in vivo. Peritoneal macrophages could also process the recombinant LCMV NP for subsequent MHC class I presentation, but were less efficient compared to the dendritic cells. Furthermore, recombinant yeast-derived virus-like particles carrying the HIV-1 V3 loop (V3-VLP), which are protenaceous and do not contain any lipid, were also found to be efficiently processed by the dendriticcell line for presentation of the class I-restricted epitope. These results clearly indicate that viral proteins, in particulate form or associated with cell debris, are processed by dendritic cells for CTL induction.

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Documento generato il 28/11/20 alle ore 21:55:12