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Titolo:
THE EFFECT OF QUISQUALIC ACID-INDUCED LESIONS OF THE NUCLEUS BASALIS MAGNOCELLULARIS ON LATENT INHIBITION
Autore:
ROCHFORD J; SEN AP; ROUSSE I; WELNER SA;
Indirizzi:
DOUGLAS HOSP,RES CTR,6875 LASALLE BLVD VERDUN PQ H4H 1R3 CANADA MCGILL UNIV,DOUGLAS HOSP,RES CTR,DEPT PSYCHIAT MONTREAL PQ CANADA
Titolo Testata:
Brain research bulletin
fascicolo: 5, volume: 41, anno: 1996,
pagine: 313 - 317
SICI:
0361-9230(1996)41:5<313:TEOQAL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL CHOLINERGIC SYSTEM; DORSAL GLOBUS PALLIDUS; RAT CEREBRAL-CORTEX; EXCITOTOXIC LESIONS; SUBSTANTIA INNOMINATA; VISUAL-DISCRIMINATION; ATTENTIONAL FUNCTION; AMINO-ACIDS; FOREBRAIN; MEMORY;
Keywords:
STIMULUS FILTERING; STIMULUS PROCESSING; CONDITIONED EMOTIONAL RESPONSE; LEARNING; MEMORY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J. Rochford et al., "THE EFFECT OF QUISQUALIC ACID-INDUCED LESIONS OF THE NUCLEUS BASALIS MAGNOCELLULARIS ON LATENT INHIBITION", Brain research bulletin, 41(5), 1996, pp. 313-317

Abstract

Latent inhibition (LI) is a reduction in the rate of acquisition of aPavlovian conditioned response that results from prior nonreinforced preexposure to a conditioned stimulus (CS), LI has been suggested to reflect the operation of mechanisms involved in stimulus selection for subsequent cognitive processing. The present experiment was conducted to assess the effect of bilateral lesions of the nucleus basalis magnocellularis (NBM) on LI employing a conditioned emotional response paradigm. Bilateral lesions of the NBM were produced by administration of 0.12 M quisqualic acid and resulted in decreased cortical acetylcholinesterase staining, as well as a 40% reduction in cortical choline acetyltransferase activity, Following lever press training, preexposed animals received 40 presentations of a 60-s tone CS, Nonpreexposed animals received no tone presentations. Acquisition of conditioned suppression was then assessed over the course of 4 tone-shock (0.6 mA, 0.5 s) pairings, Control, preexposed animals displayed a retarded rate of acquisition in comparison to nonpreexposed controls, thereby demonstratingthat the parameters used in the present experiment produced LI, In contrast, lesioned animals preexposed to the CS acquired conditioned suppression as readily as nonpreexposed lesioned animals, However, the acquisition of conditioned suppression in both lesioned groups was foundto be similar to that displayed in the preexposed control group, Thispattern of results was interpreted as being attributable to a lesion-induced impairment in the ability to maintain stimulus processing, rather than a deficit in the ability to filter a stimulus. Copyright (C) 1996 Elsevier Science Inc.

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Documento generato il 13/07/20 alle ore 11:06:47