Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DOPAMINE RECEPTOR-MEDIATED REGULATION OF CORTICOTROPIN-RELEASING HORMONE NEURONS IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS
Autore:
EATON MJ; CHEUNG S; MOORE KE; LOOKINGLAND KJ;
Indirizzi:
MICHIGAN STATE UNIV,DEPT PHARMACOL & TOXICOL,B-436 LIFE SCI BLDG E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT PHARMACOL & TOXICOL E LANSING MI 48824
Titolo Testata:
Brain research
fascicolo: 1, volume: 738, anno: 1996,
pagine: 60 - 66
SICI:
0006-8993(1996)738:1<60:DRROCH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOS-LIKE IMMUNOREACTIVITY; MESSENGER-RNA; RAT-BRAIN; IMMOBILIZATION STRESS; EFFERENT PROJECTIONS; ZONA INCERTA; C-FOS; EXPRESSION; AMYGDALA; LOCALIZATION;
Keywords:
FOS; IMMUNOHISTOCHEMISTRY; CORTICOTROPIN-RELEASING HORMONE MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Eaton et al., "DOPAMINE RECEPTOR-MEDIATED REGULATION OF CORTICOTROPIN-RELEASING HORMONE NEURONS IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS", Brain research, 738(1), 1996, pp. 60-66

Abstract

The present study examined the effects of intraperitoneal administration of selective D1 (SKF 38393) and D2 (quinelorane) dopaminergic receptor agonists on Fos-like immunoreactivity (Fos-LI) and levels of corticotropin-releasing hormone (CRH) mRNA in the paraventricular nucleus of the hypothalamus (PVN) and in the central nucleus of the amygdala (cAMY). Ninety minutes after administration of the D1 agonist SKF 38393, Fos-LI was increased in both tile PVN and cAMY. Administration of SCH 39166, a selective DI antagonist, blocked and attenuated the SKF 38393-induced increase in Fos-LI in the PVN and cAMY, respectively. Similarly, 90 minutes after intraperitoneal injection of the D2 agonist quinelorane, Fos-LI was increased in both PVN and cAMY. Administration ofthe selective D2 antagonist raclopride prevented the ability of quinelorane to increase Fos-LI in the PVN and cAMY. Both SKF 38393 and quinelorane stimulated the expression of CRH mRNA in the PVN, but failed to alter its expression in the cAMY. Taken together, these results indicate that stimulation of either D1 or D2 dopaminergic receptors activates CRH neurons in the PVN. Stimulation of either D1 or D2 receptors activates neurons in the cAMY, but these changes do not appear to be occurring in CRH neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:43:48