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Titolo:
IDENTIFICATION OF INTERLEUKIN-6 AS A FACTOR THAT INDUCES NEURITE OUTGROWTH BY PC12 CELLS PRIMED WITH NGF
Autore:
IHARA S; IWAMATSU A; FUJIYOSHI T; KOMI A; YAMORI T; FUKUI Y;
Indirizzi:
UNIV TOKYO,DEPT APPL BIOL CHEM,BIOL CHEM LAB,DIV AGR & LIFE SCI,BUNKYO KU,1-1-1 YAYOI CHO TOKYO 113 JAPAN UNIV TOKYO,DEPT APPL BIOL CHEM,BIOL CHEM LAB,DIV AGR & LIFE SCI,BUNKYO KU TOKYO 113 JAPAN KIRIN BREWERY CO LTD,CENT LABS KEY TECHNOL,KANAZAWA KU YOKOHAMA KANAGAWA 236 JAPAN JAPANESE FDN CANC RES,TOSHIMA KU TOKYO 170 JAPAN
Titolo Testata:
Journal of Biochemistry
fascicolo: 5, volume: 120, anno: 1996,
pagine: 865 - 868
SICI:
0021-924X(1996)120:5<865:IOIAAF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; NEURONAL DIFFERENTIATION; PHEOCHROMOCYTOMA CELLS; LINE; ESTABLISHMENT; PROTEINS;
Keywords:
DIFFERENTIATION; IL6; NEURITE; NGF; PC12 CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
S. Ihara et al., "IDENTIFICATION OF INTERLEUKIN-6 AS A FACTOR THAT INDUCES NEURITE OUTGROWTH BY PC12 CELLS PRIMED WITH NGF", Journal of Biochemistry, 120(5), 1996, pp. 865-868

Abstract

We have screened for a factor that induces neurite outgrowth by PC12 cells only after NGF pretreatment in the supernatants of 38 transformed cell lines, finding three positive clones, The factor showing the strongest activity was purified and identified as IL6, In this NGF-IL6 system, the process of neurite outgrowth by PC12 cells can be separatedinto NGF-dependent and IL6-dependent steps, The IL6-dependent step requires RNA synthesis, suggesting that IL6 induces new gene expression depending on NGF-priming. These findings suggest that the gene expression during the differentiation process is regulated by at least two signals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:36:08