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Titolo:
PLASTIC RESPONSES OF NEONATAL 5-HYDROXYTRYPTAMINE(1B) RECEPTORS TO 5,7-DIHYDROXYTRYPTAMINE LESIONS MAPPED BY QUANTITATIVE AUTORADIOGRAPHY
Autore:
PRANZATELLI MR; DURKIN MM; FARMER M;
Indirizzi:
NATL PEDIAT MYOCLONUS CTR,1828 L ST NW,SUITE 402 WASHINGTON DC 20036 GEORGE WASHINGTON UNIV,DEPT PHARMACOL WASHINGTON DC 20052 GEORGE WASHINGTON UNIV,DEPT NEUROL WASHINGTON DC 20052 GEORGE WASHINGTON UNIV,DEPT PEDIAT WASHINGTON DC 20052 SYNAPT PHARMACEUT CO PARAMUS NJ 00000
Titolo Testata:
International journal of developmental neuroscience
fascicolo: 5, volume: 14, anno: 1996,
pagine: 621 - 629
SICI:
0736-5748(1996)14:5<621:PRON5R>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; BINDING-SITES; I-125 IODOCYANOPINDOLOL; SEROTONIN RECEPTORS; BRAIN; NEURONS; TERMINALS; RU-24969; AGONIST; AUTORECEPTORS;
Keywords:
5-HT1B SITES; 5,7-DHT; NEONATAL BRAIN LESIONS; SUBSTANTIA NIGRA; BASAL GANGLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Pranzatelli et al., "PLASTIC RESPONSES OF NEONATAL 5-HYDROXYTRYPTAMINE(1B) RECEPTORS TO 5,7-DIHYDROXYTRYPTAMINE LESIONS MAPPED BY QUANTITATIVE AUTORADIOGRAPHY", International journal of developmental neuroscience, 14(5), 1996, pp. 621-629

Abstract

We previously found different effects on behavior, serotonin (5-HT) concentrations, 5-HT uptake sites, and 5-HT1A binding sites of neonatal5,7-dihydroxytryptamine (5,7-DHT) lesions depending on the route of 5,7-DHT injection. To study the impact of early lesions on 5-HT1B sitesas putative 5-HT terminal autoreceptors, we labelled them autoradiographically with [H-3]5-HT 4 months after intraperitoneal (i.p.) or intracisternal (i.c.) 5,7-DHT injection during the first postnatal week and quantitated specific binding in 22 brain regions. Changes were confined to the subiculum and substantia nigra, regions with the most 5-HT1B-specific binding and projection areas of structures with high mRNA expression. Both routes of 5,7-DHT injection were associated with increases in specific binding in subiculum (24% for i.p. and 47% for i.c. route). In contrast, there was a 32% increase in specific binding in the substantia nigra in rats with lesions made i.c. but not i.p. No significant differences were found in nucleus accumbens, caudate-putamen or other brain areas. In saturation homogenate binding studies of 5-HT1B sites using [I-125]iodocyanopindolol 1 month after i.p. injections, neonatal 5,7-DHT lesions did not significantly alter B-max or K-d in the neocortex, striatum, diencephalon or brainstem. These data indicatethe differential effects of the route of neonatal 5,7-DHT injections on plasticity of 5-HT1B receptor recognition sites and suggest the presence of a subpopulation of post-synaptically located 5-HT1B sites which increases in response to denervation. The data also suggest that sprouting of 5-HT neurons after neonatal 5,7-DHT lesions does not involve 5-HT1B sites. Copyright (C) 1996 ISDN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:22:59