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Titolo:
CLINICAL-EVALUATION OF THE FECAL ELASTASE TEST IN THE DIAGNOSIS AND STAGING OF CHRONIC-PANCREATITIS
Autore:
GLASBRENNER B; SCHON A; KLATT S; BECKH K; ADLER G;
Indirizzi:
UNIV ULM,DEPT INTERNAL MED,ROBERT KOCH STR 8 D-89081 ULM GERMANY UNIV ULM,DEPT INTERNAL MED 1 D-89081 ULM GERMANY
Titolo Testata:
European journal of gastroenterology & hepatology
fascicolo: 11, volume: 8, anno: 1996,
pagine: 1117 - 1120
SICI:
0954-691X(1996)8:11<1117:COTFET>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSUFFICIENCY; CHYMOTRYPSIN;
Keywords:
FECAL ELASTASE TEST; FECAL CHYMOTRYPSIN; PANCREOLAURYL SERUM TEST; EXOCRINE PANCREATIC FUNCTION; CHRONIC PANCREATITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
B. Glasbrenner et al., "CLINICAL-EVALUATION OF THE FECAL ELASTASE TEST IN THE DIAGNOSIS AND STAGING OF CHRONIC-PANCREATITIS", European journal of gastroenterology & hepatology, 8(11), 1996, pp. 1117-1120

Abstract

Objective: To test the diagnostic accuracy of faecal elastase (FE), anew test of exocrine pancreatic function, abdominal complaints. Methods: Between January 1994 and December 1995, 131 patients (age range 17-82 years) were submitted for exocrine pancreatic function testing. Sixty-three patients had a firm diagnosis of chronic pancreatitis (CP) at stage I-III according to endoscopic retrograde cholangiopancreatography (ERCP). Twenty patients suffered from other pancreatic diseases (PD), and 48 patients had various other gastrointestinal diseases (GD). Fifty-seven healthy controls (HC) were also investigated. Stool speci mens were analysed for FE by enzyme-linked immunosorbent assay (ELISA)and for faecal chymotrypsin (FC). The pancreolauryl serum test (PLT) was also performed in 97 patients and 23 healthy controls. Results: FEwas 200; 45-500 mu g/g (median; range) in CP-I (n = 19), 94; 0-400 mug/g in CP-II (n = 14) and 38; 0-135 mu g/g in CP-III patients (n = 30). With a cutoff of 200 mu g/g, abnormal test results were found in 47% of CP-I, 79% of CP-II and 100% of CP-III patients; in 30% of PD patients, in 38% of GD patients and in 7% of HC. Sensitivity of abnormal FE in diagnosing CP was 79% (FC: 48%; PLT: 71%). The specificity of only 62% (FC: 73%; PLT: 67%) in the CD group increased to 78% (FC: 81%; PLT: 77%) when patients with small bowel diseases and diarrhoea (n = 22) were excluded. Conclusion: Faecal elastase is more sensitive than chymotrypsin and comparable to the pancreolauryl test in the diagnosis of chronic pancreatitis. Indirect exocrine pancreatic function tests are not helpful to differentiate between pancreatic and small bowel diseases in a prospective population of patients with abdominal complaints.

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Documento generato il 12/07/20 alle ore 06:24:35