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Titolo:
METASTATIC POTENTIAL OF LYMPHOMA LEUKEMIA CELL-LINES IN SCID MICE IS CLOSELY-RELATED TO EXPRESSION OF CD44/
Autore:
KAWASAKI N; MATSUO Y; YOSHINO T; YANAI H; OKA T; TERAMOTO N; LIU C; KONDO E; MINOWADA J; AKAGI T;
Indirizzi:
OKAYAMA UNIV,SCH MED,DEPT PATHOL,2-5-1 SHIKATA CHO OKAYAMA 700 JAPAN HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL BANK CTR OKAYAMA 702 JAPAN
Titolo Testata:
Japanese journal of cancer research
fascicolo: 10, volume: 87, anno: 1996,
pagine: 1070 - 1077
SICI:
0910-5050(1996)87:10<1070:MPOLLC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE HOMING RECEPTOR; NON-HODGKINS-LYMPHOMA; ADHESION MOLECULES; L-SELECTIN; IMMUNE-SYSTEM; BINDING; RECOGNITION; MIGRATION; ENDOTHELIUM; SPECIFICITY;
Keywords:
MALIGNANT LYMPHOMA; ADHESION MOLECULE; HERMES-3; METASTASIS; ANIMAL MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
N. Kawasaki et al., "METASTATIC POTENTIAL OF LYMPHOMA LEUKEMIA CELL-LINES IN SCID MICE IS CLOSELY-RELATED TO EXPRESSION OF CD44/", Japanese journal of cancer research, 87(10), 1996, pp. 1070-1077

Abstract

To investigate whether the lymphocyte homing receptors, adhesion molecules regulating normal lymphocyte traffic, influence the dissemination of lymphoma cells, 24 lymphoma/leukemia cell lines were inoculated into SCID mice subcutaneously, and the correlation between the expression of the adhesion molecules and the metastatic potential of the cell lines was examined. Among the six adhesion molecules examined (LFA-1, ICAM-1, CLA, VLA-4, L-selectin and CD44), L-selectin increased the incidence of lymph node metastasis, and CD44 expression was related to both lymph node and organ (hematogenous) metastasis. A monoclonal antibody to the standard form of CD44 (CD44s), Hermes-3, inhibited the localgrowth and remote metastasis of CD44(+) cell lines. Thus, it is concluded that at least CD44s expression is important in both lymphatic andhematogenous metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:30:23