Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THERAPEUTIC OPTIONS AFTER FAILED HELICOBACTER-PYLORI ERADICATION THERAPY
Autore:
VANDERHULST RWM; WEEL JFL; VANDERENDE A; TENKATE FJW; DANKERT J; TYTGAT GNJ;
Indirizzi:
UNIV AMSTERDAM,ACAD MED CTR,DEPT GASTROENTEROL,MEIBERGDREEF 9 NL-1105AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT MED MICROBIOL NL-1105 AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT HISTOPATHOL NL-1105 AZ AMSTERDAM NETHERLANDS
Titolo Testata:
The American journal of gastroenterology
fascicolo: 11, volume: 91, anno: 1996,
pagine: 2333 - 2337
SICI:
0002-9270(1996)91:11<2333:TOAFHE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIC-ULCER; DOUBLE-BLIND; AMOXICILLIN; OMEPRAZOLE; INFECTION; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
R.W.M. Vanderhulst et al., "THERAPEUTIC OPTIONS AFTER FAILED HELICOBACTER-PYLORI ERADICATION THERAPY", The American journal of gastroenterology, 91(11), 1996, pp. 2333-2337

Abstract

Objectives: Many of the currently used Helicobacter pylori eradication regimens fail to cure 5-20% of the patients, Those patients will remain at risk of developing a potentially fatal complication of peptic ulcer disease. Therefore, a new attempt to cure H. pylori infection after initial failure of therapy is indicated, We studied the efficacy ofthree retreatment regimens after initial failure of omeprazole-amoxicillin dual therapy. Methods: Fifty-three patients whose treatment failed were randomly assigned to receive retreatment with the same regimenof omeprazole 20 mg b.i.d. (group I) or omeprazole 40 mg t.i.d. (group II) plus amoxicillin 750 mg t.i.d. for 14 days. Forty patients in whom the omeprazole-amoxicillin retreatment failed were assigned to receive omeprazole 20 mg b.i.d., amoxicillin 750 mg t.i.d., and metronidazole 500 mg t.i.d. for 14 days (group III) or omeprazole 20 mg b.i.d. plus clarithromycin 500 mg t.i.d. for 14 days (group IV), H. pylori infection was assessed by culture and histology of gastric biopsies before and 4-6 wk after cessation of therapy. Susceptibility of H. pylori to amoxicillin, clarithromycin, and metronidazole was determined by theE test, Results: In groups I (n = 28) and II (n = 25), cure of H. pylori infection was achieved in 21% and 28% of patients, respectively (not significant). In groups III (n = 20) and IV (n = 20), H. pylori infection was cured in 75% and 70%, respectively, Conclusions: Retreatment with an identical omeprazole-amoxicillin dual regimen is of limited benefit, a result that is independent of the omeprazole dose. In contrast, a third H. pylori eradication attempt with omeprazole-clarithromycin dual therapy or omeprazole-amoxicillin-metronidazole triple therapy provides reasonable cure rates after failure of omeprazole-amoxicillin dual therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:24:53