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Titolo:
AN INVESTIGATION INTO THE CRITICAL SURFACTANT CONCENTRATION FOR SOLIDSOLUBILITY OF HYDROPHOBIC DRUG IN DIFFERENT POLYETHYLENE GLYCOLS
Autore:
WULFF M; ALDEN M; CRAIG DQM;
Indirizzi:
UNIV UPPSALA,CTR BIOMED,DEPT PHYS & INORGAN PHARMACEUT CHEM,BOX 574 S-75123 UPPSALA SWEDEN UNIV UPPSALA,CTR BIOMED,DEPT PHYS & INORGAN PHARMACEUT CHEM S-75123 UPPSALA SWEDEN UNIV LONDON,SCH PHARM,CTR MAT SCI LONDON WC1N 1AX ENGLAND
Titolo Testata:
International journal of pharmaceutics
fascicolo: 2, volume: 142, anno: 1996,
pagine: 189 - 198
SICI:
0378-5173(1996)142:2<189:AIITCS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM DODECYL-SULFATE; PHYSICOCHEMICAL ASPECTS; DISPERSIONS; GRISEOFULVIN; DISSOLUTION; ADDITIONS; RELEASE; SYSTEMS;
Keywords:
CRYSTALLINITY; SOLID SOLUTION; ALKALI DODECYL SULFATES; GRISEOFULVIN; X-RAY POWDER DIFFRACTION; ODSC; MTDSC; DIELECTRIC SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M. Wulff et al., "AN INVESTIGATION INTO THE CRITICAL SURFACTANT CONCENTRATION FOR SOLIDSOLUBILITY OF HYDROPHOBIC DRUG IN DIFFERENT POLYETHYLENE GLYCOLS", International journal of pharmaceutics, 142(2), 1996, pp. 189-198

Abstract

Solid dispersions of 10% w/w griseofulvin in different polyethylene glycols (PEGs) with or without incorporation of alkali dodecyl sulphates (MDS) were prepared by the melting method. The investigations concerned the solid state (X-ray powder diffraction), the transition from solid to liquid stale (Oscillating DSC) and the liquid state (low frequency dielectric spectroscopy). The critical concentrations of SDS for the formation of solid solutions in varying PEGs were evaluated. In PEG3000 this formation occurs at 1.4% w/w SDS, whereas PEG 6000 and PEG 20000 require solely 1.0% ww SDS to transfer a dispersion into a solidsolution. PEG 3000 was also investigated with the addition of MDS. The critical surfactant concentrations for the formation of solid solutions with the counterions Li+, Na+ and K+ were 1.0%, 1.4% and 2.1% w/w,respectively. The investigated systems had varying degrees of crystallinity. With the addition of SDS to PEGs with a range of molecular weights, the highest crystallinity was seen in the PEG 3000 sample. The different polymers contained different amounts of folded and extended chains which influences the amount of amorphous material within the polymer structure. When surfactants with different counterions were addedto PEG 3000, the lithium sample showed the highest crystallinity. In the melt the Li+ sample showed the lowest dielectric mobility. The results show that concentration and structure of surfactant together withthe presence of folded and extended chains form the conditions for the formation of solid solutions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:06:38