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Titolo:
THE PEPTIDE PQFYRFAMIDE IS ENCODED ON THE FMRFAMIDE PRECURSOR OF THE SNAIL HELIX-ASPERSA BUT DOES NOT ACTIVATE THE FMRFAMIDE-GATED SODIUM CURRENT
Autore:
PRICE DA; DOBLE KE; LESSER W; GREENBERG MJ; SWIDEREK KM; LEE TD; LUTZ EM; SOMMERVILLE J; FALCONER S; COTTRELL GA;
Indirizzi:
UNIV FLORIDA,WHITNEY LAB,9505 OCEAN SHORE BLVD ST AUGUSTINE FL 32086 CITY HOPE NATL MED CTR,BECKMAN RES INST DUARTE CA 91010 UNIV ST ANDREWS,SCH BIOL & MED SCI ST ANDREWS KY16 9TS FIFE SCOTLAND
Titolo Testata:
The Biological bulletin
fascicolo: 3, volume: 191, anno: 1996,
pagine: 341 - 352
SICI:
0006-3185(1996)191:3<341:TPPIEO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE PHE-MET-ARG-PHE-NH2 FMRFAMIDE; MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE; MUTUALLY EXCLUSIVE EXPRESSION; CARDIOACTIVE PEPTIDES; LYMNAEA-STAGNALIS; NEURONS; GENE; APLYSIA; CHANNEL; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Price et al., "THE PEPTIDE PQFYRFAMIDE IS ENCODED ON THE FMRFAMIDE PRECURSOR OF THE SNAIL HELIX-ASPERSA BUT DOES NOT ACTIVATE THE FMRFAMIDE-GATED SODIUM CURRENT", The Biological bulletin, 191(3), 1996, pp. 341-352

Abstract

The complete sequence of the FMRFamide precursor cDNA from Helix aspersa is reported here. Since the 5' end of this cDNA is identical to that of the precursor that encodes the heptapeptide analogs of FLRFamide, the two transcripts are probably derived by alternative RNA splicing. A novel pentapeptide, Glp-Phe-Tyr-Arg-Phe-NH2 (pQFYRFamide), predicted from the cDNA sequence, was purified from extracts of H. aspersa ganglia and identified by mass spectroscopy, Partial gene sequences for the FMRFamide precursors of two closely related pulmonate species-Cepaea nemoralis and Polydontes acutangula-were also determined and compared with the cDNA sequence of H. aspersa and a partial gene sequence previously determined from H. pomatia. Not only are the FMRFamide-related sequences and proteolytic processing sites conserved, but the lineararrangement of these landmarks is also retained. Synthetic pQFYRFamide has some effects on the isolated heart and on neuronal potassium currents in H. aspersa that are similar to those of FMRFamide, but it does not activate the neuronal FMRFamide-gated sodium channel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:57:26