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Titolo:
BARORECEPTOR CONTROL OF THE CUTANEOUS ACTIVE VASODILATOR SYSTEM
Autore:
CRANDALL CG; JOHNSON JM; KOSIBA WA; KELLOGG DL;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT MED SAN ANTONIO TX 78284
Titolo Testata:
Journal of applied physiology
fascicolo: 5, volume: 81, anno: 1996,
pagine: 2192 - 2198
SICI:
8750-7587(1996)81:5<2192:BCOTCA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY NEGATIVE-PRESSURE; FOREARM VASCULAR-RESISTANCE; CAROTID BAROREFLEX CONTROL; SYMPATHETIC ACTIVITY; VASOCONSTRICTOR RESPONSES; MUSCLE VASOCONSTRICTION; AORTIC BAROREFLEX; LOCAL TEMPERATURE; SKELETAL-MUSCLE; HEART-RATE;
Keywords:
SKIN BLOOD FLOW; BAROREFLEX; HUMAN; CARDIOPULMONARY BARORECEPTORS; CAROTID; TEMPERATURE REGULATION; PERIPHERAL CIRCULATION; BRETYLIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
C.G. Crandall et al., "BARORECEPTOR CONTROL OF THE CUTANEOUS ACTIVE VASODILATOR SYSTEM", Journal of applied physiology, 81(5), 1996, pp. 2192-2198

Abstract

We sought to identify whether reductions in cutaneous active vasodilation during simulated orthostasis could be assigned solely to cardiopulmonary or to carotid baroreflexes by unloading cardiopulmonary baroreceptors with low levels of lower body negative pressure (LBNP or unloading carotid baroreceptors with external pressure applied over the carotid sinus area [carotid pressure (CP)]. Skin blood flow was measured at a site at which adrenergic function was blocked via bretylium tosylate iontophoresis and at an unblocked site. During LBNP of -5 and -10 mmHg in hyperthermia, neither heart rate (HR) nor cutaneous vascular conductance (CVC) at either site changed (P > 0.05 for both), whereas forearm vascular conductance (FVC) was reduced (-5 mmHg: from 21.6 +/- 4.8 to 19.8 +/- 4.1 FVC units, P = 0.05; -10 mmHg: from 22.3 +/- 4.0 to 19.3 +/- 3.7 FVC units, P = 0.002). LBNP of -30 mmHg in hyperthermiareduced CVC at both sites (untreated: from 51.9 +/- 5.7 to 43.2 +/- 5,1% maximum, P = 0.02; bretylium tosylate: from 60.9 +/- 5.4 to 53.2 +/- 4.4% maximum, P = 0,02), reduced FVC (from 23.2 +/- 3.6 to 18.1 +/-8.3 FVC units; P = 0.002), and increased HR (from 83 +/- 4 to 101 +/-3 beats/min; P = 0.003). Pulsatile CP (45 mmHg) did not affect FVC orCVC during normothermia or hyperthermia (P > 0.05). However, HR and mean arterial pressure were elevated during CP in both thermal conditions (both P < 0.05). These results suggest that neither selective low levels of cardiopulmonary baroreceptor unloading nor selective carotid baroreceptor unloading can account for the inhibition of cutaneous active vasodilator activity seen with simulated orthostasis.

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Documento generato il 03/12/20 alle ore 05:38:20