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Titolo:
CYTOCHROME-C MESSENGER-RNA IN SKELETAL-MUSCLES OF IMMOBILIZED LIMBS
Autore:
BOOTH FW; LOU W; HAMILTON MT; YAN Z;
Indirizzi:
UNIV TEXAS,SCH MED,CTR HLTH SCI,DEPT INTEGRAT BIOL,4100 MSB,6431 FANNIN HOUSTON TX 77030
Titolo Testata:
Journal of applied physiology
fascicolo: 5, volume: 81, anno: 1996,
pagine: 1941 - 1945
SICI:
8750-7587(1996)81:5<1941:CMISOI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFERENT LENGTHS; BIOCHEMICAL ADAPTATIONS; ENDURANCE EXERCISE; MUSCULAR-ATROPHY; PROTEIN; EXPRESSION; GENE;
Keywords:
ATROPHY; MITOCHONDRIA; GENE EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
F.W. Booth et al., "CYTOCHROME-C MESSENGER-RNA IN SKELETAL-MUSCLES OF IMMOBILIZED LIMBS", Journal of applied physiology, 81(5), 1996, pp. 1941-1945

Abstract

Even though immobilization of a slow skeletal muscle in a lengthened position prevents muscle atrophy, it is unknown whether this treatmentwould prevent a decrease in mitochondrial quantity. We found that, regardless of muscle length in immobilized limbs, the mRNA of a marker for mitochondrial quantity, cytochrome c, decreased. Cytochrome c mRNA per milligram of muscle was 62 and 72% less 1 wk after fixation of thesoleus muscle in shortened and lengthened positions, respectively, than age-matched controls. Cytochrome c mRNA per milligram wet weight was 36 and 32% less in the tibialis anterior muscle fixed for 1 wk in the shortened and length ened positions, respectively, compared with age-matched controls. Recently, in the 3'-untranslated region of cytochrome c mRNA a novel RNA-protein interaction that decreases in chronically stimulated rat skeletal muscle was identified.[Z. Yan, S. Salmons, Y. L. Dang, M. T. Hamilton, and F. W. Booth. Am. J. Physiol. 271 (Cell Physiol. 40): C1157-C1166, 1996]. The RNA-protein interaction in the 3'-untranslated region of cytochrome c mRNA in soleus and tibialis anterior muscles was unaffected by fixation in either shortened or lengthened position. We conclude that, whereas lengthening muscle during limbfixation abates the loss of total muscle protein, the percentage decrease in cytochrome c mRNA is proportionally greater than total protein. This suggests that the design of countermeasures to muscle atrophy should include different exercises to maintain total protein and mitochondria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 12:26:28