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Titolo:
DIFFERENT ROLES FOR CD4(-LYMPHOCYTES AND MACROPHAGE SUBSETS IN THE CONTROL OF A GENERALIZED VIRUS-INFECTION() AND CD8(+) T)
Autore:
KARUPIAH G; BULLER RML; VANROOIJEN N; DUARTE CJ; CHEN JH;
Indirizzi:
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV CELL BIOL & IMMUNOL CANBERRA ACT 2601 AUSTRALIA NIAID,VIRAL DIS LAB BETHESDA MD 20892 FREE UNIV AMSTERDAM,FAC MED,DEPT CELL BIOL & IMMUNOL AMSTERDAM NETHERLANDS
Titolo Testata:
Journal of virology
fascicolo: 12, volume: 70, anno: 1996,
pagine: 8301 - 8309
SICI:
0022-538X(1996)70:12<8301:DRFCAM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
VACCINIA VIRUS; ECTROMELIA VIRUS; INTERFERON-GAMMA; DEFICIENT MICE; CELL RESPONSES; ANTIGEN PRESENTATION; VIRAL-INFECTION; INFLUENZA; DEPLETION; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
G. Karupiah et al., "DIFFERENT ROLES FOR CD4(-LYMPHOCYTES AND MACROPHAGE SUBSETS IN THE CONTROL OF A GENERALIZED VIRUS-INFECTION() AND CD8(+) T)", Journal of virology, 70(12), 1996, pp. 8301-8309

Abstract

The importance of T-lymphocyte subsets in the control of poxvirus infections is controversial, To determine the relative contribution of lymphocyte subsets important for recovery from infection with ectromeliavirus (EV), a natural murine poxvirus pathogen, C57BL/6 (B6) mice lacking functional CD8(+) T cells because of disruption of the beta 2-microglobulin gene or lacking functional CD4(+) T cells because of disruption of the I-A(beta) gene, acutely depleted of CD8(+) or CD4(+) T cells with monoclonal antibody, or depleted of macrophage subsets by the macrophage suicide technique were used, Recovery from infection was strictly dependent on the effector functions of CD8(+) T cells, in the absence of which 100% mortality resulted, This lymphocyte population had demonstrable antiviral activity early in the infection process even before class I major histocompatibility complex (MHC)-restricted CD8(+) cytotoxic T-lymphocyte (CTL) activity was detectable, CD4(+) T cellswere found to be necessary for the generation of an optimal virus-specific, class I MHC-restricted CD8(+) CTL response and contributed to virus clearance not involving cytolytic mechanisms, In both models of CD4(+) T-cell deficiency, virus clearance was incomplete and persisted at low levels in most organs and at very high levels in the skin, but the animals did not die, The elimination of macrophage subpopulations impeded virus clearance, impaired the generation of class I MHC-restricted antiviral CTL response, and resulted in 100% mortality, These findings establish an absolute requirement for CD8(+) and CD4(+) T lymphocytes and macrophage subsets in the elimination of a natural murine poxvirus infection and support the idea that macrophages may be essential accessory cells for the generation of class I MHC-restricted antiviral CTL responses.

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Documento generato il 29/11/20 alle ore 10:18:18