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Titolo:
WATER-SOLUBLE NAPHTHALENE DERIVATIVES AS SINGLET OXYGEN (O-1(2), (1)DELTA(G)) CARRIERS FOR BIOLOGICAL MEDIA
Autore:
PIERLOT C; HAJJAM S; BARTHELEMY C; AUBRY JM;
Indirizzi:
FAC PHARM LILLE,EQUIPE RECH RADICAUX LIBRES & OXYGENE SINGULET,URA CNRS 351 F-59006 LILLE FRANCE FAC PHARM LILLE,EQUIPE RECH RADICAUX LIBRES & OXYGENE SINGULET,URA CNRS 351 F-59006 LILLE FRANCE PHARM GALEN & BIOPHARM LAB F-59006 LILLE FRANCE
Titolo Testata:
Journal of photochemistry and photobiology.B, Biology
fascicolo: 1, volume: 36, anno: 1996,
pagine: 31 - 39
SICI:
1011-1344(1996)36:1<31:WNDASO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROGEN-PEROXIDE; SUPEROXIDE ION; DNA; CONSEQUENCES;
Keywords:
SINGLET OXYGEN; NAPHTHALENE ENDOPEROXIDES; SINGLET OXYGEN CARRIERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
C. Pierlot et al., "WATER-SOLUBLE NAPHTHALENE DERIVATIVES AS SINGLET OXYGEN (O-1(2), (1)DELTA(G)) CARRIERS FOR BIOLOGICAL MEDIA", Journal of photochemistry and photobiology.B, Biology, 36(1), 1996, pp. 31-39

Abstract

The synthesis of anionic, cationic, and non-ionic water-soluble naphthalene derivative are described. Their water solubility at 37 degrees C is always greater than 10(-2) M. The corresponding endoperoxides areprepared by chemical oxidation (H2O2/Na2MoO4) Or by photo-oxidation (O-2/h nu/photosensitizer). The overall rate constants, k(f) + k(q) of O-1(2) quenching by naphthalene derivatives are measured using flash photolysis. Determination of the half-times of the decomposition and the yield of O-1(2) generated from all the endoperoxides on thermolysis at 37 degrees C showed that within 2 h almost all of the trapped oxygen is released, half of which is in the excited singlet state, Diffusion rates of these carriers through an artificial lipidic membrane are about ten times lower for the ionic molecules than for the non-ionic compounds. Therefore, according to their physico-chemical properties, these naphthalene derivatives should be suitable as chemical sources of pure O-1(2) in biological media.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:31:08