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Titolo:
VISUALIZING AN OLFACTORY SENSORY MAP
Autore:
MOMBAERTS P; WANG F; DULAC C; CHAO SK; NEMES A; MENDELSOHN M; EDMONDSON J; AXEL R;
Indirizzi:
ROCKEFELLER UNIV,1230 YORK AVE NEW YORK NY 10021 COLUMBIA UNIV,COLL PHYS & SURG,HOWARD HUGHES MED INST,DEPT BIOCHEM & MOL BIOPHYS NEW YORK NY 10032 COLUMBIA UNIV,COLL PHYS & SURG,CTR NEUROBIOL & BEHAV NEW YORK NY 10032
Titolo Testata:
Cell
fascicolo: 4, volume: 87, anno: 1996,
pagine: 675 - 686
SICI:
0092-8674(1996)87:4<675:VAOSM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ODORANT RECEPTOR EXPRESSION; MITRAL TUFTED CELLS; NUCLEOTIDE-SEQUENCE; GENE-EXPRESSION; BULB; MOUSE; NEURONS; ORGANIZATION; EPITHELIUM; MOLECULES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
P. Mombaerts et al., "VISUALIZING AN OLFACTORY SENSORY MAP", Cell, 87(4), 1996, pp. 675-686

Abstract

We have developed a genetic approach to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they projectto the olfactory bulb. Neurons expressing a specific receptor projectto only two topographically fixed loci among the 1800 glomeruli in the mouse olfactory bulb. Our data provide direct support for a model inwhich a topographic map of receptor activation encodes odor quality in the olfactory bulb. Receptor swap experiments suggest that the olfactory receptor plays an instructive role in the guidance process but cannot be the sole determinant in the establishment of this map. This genetic approach may be more broadly applied to visualize the development and plasticity of projections in the mammalian nervous system.

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Documento generato il 14/07/20 alle ore 05:35:11