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Titolo:
EVALUATION OF NONINVASIVE TECHNIQUES TO ASSESS VASOCONSTRICTION IN HEALTHY-VOLUNTEERS USING METHOXAMINE AS A PROBE DRUG
Autore:
DIXON RM; MEIRE HB; LEIGH C; POSNER J; ROLAN PE;
Indirizzi:
ZENECA PHARMACEUT,DEPT CLIN PHARMACOL,ALDERLY PK MACCLESFIELD SK10 4TG CHESHIRE ENGLAND WELLCOME RES LABS,DEPT CLIN PHARMACOL BECKENHAM BR3 3BS KENT ENGLAND COLL HOSP,DEPT ULTRASOUND LONDON ENGLAND
Titolo Testata:
Cephalalgia
fascicolo: 7, volume: 16, anno: 1996,
pagine: 507 - 517
SICI:
0333-1024(1996)16:7<507:EONTTA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
THORACIC ELECTRICAL BIOIMPEDANCE; BLOOD-PRESSURE; CORONARY CIRCULATION; STROKE VOLUME; SUMATRIPTAN; HEMODYNAMICS; MIGRAINE; AGONIST; FINGER;
Keywords:
CARDIOVASCULAR METHODS; HEALTHY VOLUNTEERS; METHOXAMINE; VASOCONSTRICTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Dixon et al., "EVALUATION OF NONINVASIVE TECHNIQUES TO ASSESS VASOCONSTRICTION IN HEALTHY-VOLUNTEERS USING METHOXAMINE AS A PROBE DRUG", Cephalalgia, 16(7), 1996, pp. 507-517

Abstract

Non-invasive methods for assessment of the vascular effects of antimigraine drugs were evaluated with respect to their utility, variabilityand sensitivity in a double-blind, placebo-controlled, three-period crossover study in six healthy volunteers using an intravenous vasoconstrictor, methoxamine, as a probe drug. Changes in the internal diameter of the brachial and radial arteries were measured using ultrasound which had low between-day and within-day coefficients of variation. Peak systolic velocity (PSV), time-averaged velocity (TAV), total flow, resistance (RI) and pulsatility indices (PI) were measured by Doppler from one arterial wave form. Whilst PSV and TAV increased with methoxamine, because of bradycardia, changes in PI and RI were difficult to interpret. An automatic oscillometric cuff, a mercury-in-silastic straingauge method and the ''Finapres'', finger arterial blood pressure monitor were used to follow changes in systolic blood pressure (SBP). Thestrain gauge technique underestimated arm SBP compared to the oscillometric method but clearly showed drug-related increases whilst the Finapres did not reflect changes in blood pressure detected by the other methods.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:55:18