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Titolo:
HYPOFRACTIONATED RADIOTHERAPY WITH CONCURRENT 5-FLUOROURACIL RADIOSENSITIZATION FOR RECURRENT OR LOCALLY ADVANCED COLORECTAL-CANCER - A PHASE-II STUDY
Autore:
SKARLATOS J; KOSMA L; KOUKOURAKIS M; ZAMBATIS C; KAPSORITAKIS A; MOUDER N; YANNAKAKIS D;
Indirizzi:
UNIV HOSP IRAKLION,DEPT RADIOTHERAPY & ONCOL,POB 1352 IRAKLION 71110 GREECE ST SAVAS HOSP,HELLEN CANC INST,DEPT RADIOTHERAPY & ONCOL ATHENS GREECE
Titolo Testata:
International journal of colorectal disease
fascicolo: 5, volume: 11, anno: 1996,
pagine: 206 - 210
SICI:
0179-1958(1996)11:5<206:HRWC5R>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; VENOUS INFUSION; RECTAL-CARCINOMA; ADENOCARCINOMA; FLUOROURACIL; LEUCOVORIN; 5-FU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J. Skarlatos et al., "HYPOFRACTIONATED RADIOTHERAPY WITH CONCURRENT 5-FLUOROURACIL RADIOSENSITIZATION FOR RECURRENT OR LOCALLY ADVANCED COLORECTAL-CANCER - A PHASE-II STUDY", International journal of colorectal disease, 11(5), 1996, pp. 206-210

Abstract

In a pilot study we treated 19 patients suffering from recurrent or locally advanced inoperable colorectal cancer, with concurrent hypofractionated radiotherapy (4-5 Gy/fraction, 2 fractions per week) and 5-Fluorouracil bolus, 1 hour before RT at doses of 300 mg/m(2). For 16 patients treated with radical intent the Normalised Total Dose for alpha/beta=10 Gy ranged between 56-74 Gy (median 62 Gy). The schedule used was very well tolerated. Moderate grade II haematological toxicity was observed in 11% of cases and diarrhoea grade II/III resulting in 2-4 weeks treatment delay was observed in 26% of cases. One case with bowelperforation and one with painful subcutaneous fibrosis was observed during 12-27 months of follow-up. Out of 16 patients treated with radical intent 4 (25%) showed complete response and the overall response rate was 56% (9/16). The one year symptom free survival was obtained in 11/16 (69%) radically treated patients. It is concluded that hypofractionated radiochemotherapy with 5-Fluorouracil for recurrent or locallyadvanced colorectal cancer is an effective regimen and has acceptableacute and late toxicity. Further investigation is required.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:00:24