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Titolo:
ACUTE TOXICITY OF SYNTHETIC GYMNODINIUM BREVE TOXIN METABOLITE AND ITS ANALOGS IN MICE
Autore:
HUSAIN K; SINGH R; KAUSHIK MP; GUPTA AK;
Indirizzi:
SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL SPRINGFIELD IL 62794 DEF RES & DEV ESTAB,DIV PHARMACOL & TOXICOL GWALIOR 474002 INDIA DEF RES & DEV ESTAB,DIV SYNTHET CHEM GWALIOR 474002 INDIA
Titolo Testata:
Ecotoxicology and environmental safety
fascicolo: 1, volume: 35, anno: 1996,
pagine: 77 - 80
SICI:
0147-6513(1996)35:1<77:ATOSGB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT; BREVETOXINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
K. Husain et al., "ACUTE TOXICITY OF SYNTHETIC GYMNODINIUM BREVE TOXIN METABOLITE AND ITS ANALOGS IN MICE", Ecotoxicology and environmental safety, 35(1), 1996, pp. 77-80

Abstract

Acute toxicity of synthetic Gymnodinium breve toxin metabolite and its analogues has been investigated in mice. The anticholinesterase potencies of the toxin metabolite and its analogues were determined in vitro as well as in vivo. The intraperitoneal LD(50) of the parent metabolite ethyl-2-oxopropylidene)phosphorohydrazidothioate(E )oxime in micewas higher compared to LD(50) values of its analogues. The in vitro acetylcholinesterase (AChE)-inhibiting potency values were higher for diethoxy(P=O) analogue than for diispropoxy(P=O) analogue. Lethal dosesof parent metabolite and its analogues significantly inhibited AChE activity in the blood and brain of mice 1 hr postexposure. The maximum inhibition by the parent metabolite was observed in both tissues. The percentage inhibition of AChE activity was greater in the blood than in the brain. The results indicate that these agents have anticholinesterase action specifically in the blood. In conclusion, the parent toxin metabolite is a more potent inhibitor of AChE in vivo, whereas higher toxicity is associated with other analogues, suggesting the involvement of other factors influencing the toxicity, which needs to be further investigated. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:42:45