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Titolo:
PARTICIPATION OF AT(1) AND AT(2) RECEPTORS IN THE DIFFERENTIAL INTERACTION BETWEEN ANGIOTENSIN-II OR ANGIOTENSIN-III AND ALPHA-2-ADRENOCEPTORS IN THE NUCLEUS-RETICULARIS GIGANTOCELLULARIS IN CARDIOVASCULAR REGULATION AND ANTINOCICEPTION IN RATS
Autore:
YANG CH; SHYR MH; TAN PPC; CHAN SHH;
Indirizzi:
NATL YANG MING UNIV,CTR NEUROSCI TAIPEI 11221 TAIWAN NATL YANG MING UNIV,CTR NEUROSCI TAIPEI 11221 TAIWAN CHANG GUNG MEM HOSP,DEPT ANESTHESIA TAYUAN TAIWAN
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 279, anno: 1996,
pagine: 795 - 802
SICI:
0022-3565(1996)279:2<795:POAAAR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYPE-2 RECEPTOR; RESPONSES; GUANABENZ; BRAIN; INVOLVEMENT; MICE; ALPHA-2-ADRENOCEPTORS; HYPERTENSION; NOCICEPTION; ANALGESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
C.H. Yang et al., "PARTICIPATION OF AT(1) AND AT(2) RECEPTORS IN THE DIFFERENTIAL INTERACTION BETWEEN ANGIOTENSIN-II OR ANGIOTENSIN-III AND ALPHA-2-ADRENOCEPTORS IN THE NUCLEUS-RETICULARIS GIGANTOCELLULARIS IN CARDIOVASCULAR REGULATION AND ANTINOCICEPTION IN RATS", The Journal of pharmacology and experimental therapeutics, 279(2), 1996, pp. 795-802

Abstract

We evaluated possible interactions between angiotensin II (AII) or angiotensin III (AIII) and the alpha-2 adrenoceptors of the nucleus reticularis gigantocellularis (NRGC) in the medulla oblongata that are involved in cardiovascular regulation and antinociception, as well as theangiotensin receptor subtypes involved, using Sprague-Dawley rats that were anesthetized with pentobarbital sodium. The efficacy of guanabenz, which acts on the alpha-2 adrenoceptors in the NRGC to elicit hypotension, bradycardia and antinociception, based on tail-flick responses to noxious thermal stimuli (50 degrees C), was used as our experimental index. Bilateral microinjection of AII or AIII into the NRGC, at equimolar doses (40 pmol) that did not alter base-line systemic arterial pressure, heart rate or tail-flick latency, significantly and site-specifically attenuated the cardiovascular suppression elicited by guanabenz (100 mu g/kg i.v.). This attenuation was appreciably antagonizedby coadministration of the AT(2) receptor antagonist PD-123319 (1.6 nmol). Concomitant examination of tail-flick responses revealed discernible inhibition by AII (40 pmol), but potentiation by AIII (40 pmol), of guanabenz-induced antinociception. These differential modulating effects of AII and AIII were, however, antagonized by comicroinjection of losartan (1.6 nmol) into the bilateral NRGC. Our results suggest that both AII and AIII produced a reduction, via AT(2) receptors, of the activity of alpha-2 adrenoceptors in the NRGC that are involved in central cardiovascular regulation. On the other hand, antinociception induced by activation of alpha-2 adrenoceptors in the NRGC was suppressedby AII and potentiated by AIII, although AT(1) receptors may play a major role in both interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 03:17:11