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Titolo:
SECRETIN INHIBITS CANINE GASTRIC-ACID SECRETION IN RESPONSE TO PENTAGASTRIN BY MODULATING GASTRIC HISTAMINE-RELEASE
Autore:
GERBER JG; PAYNE NA;
Indirizzi:
UNIV COLORADO,DIV CLIN PHARMACOL & TOXICOL,HLTH SCI CTR,CAMPUS BOX C-237,4200 E 9TH AVE DENVER CO 80262
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 279, anno: 1996,
pagine: 718 - 723
SICI:
0022-3565(1996)279:2<718:SICGSI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOSTATIN-LIKE IMMUNOREACTIVITY; PERFUSED RAT STOMACH; PARIETAL-CELLS; PROSTAGLANDINS; CHOLECYSTOKININ; DOGS; ENTEROGASTRONE; POLYPEPTIDE; INVIVO; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Gerber e N.A. Payne, "SECRETIN INHIBITS CANINE GASTRIC-ACID SECRETION IN RESPONSE TO PENTAGASTRIN BY MODULATING GASTRIC HISTAMINE-RELEASE", The Journal of pharmacology and experimental therapeutics, 279(2), 1996, pp. 718-723

Abstract

The effect of secretin an pentagastrin- and gastrin-stimulated gastric histamine release and acid secretion was examined in the anesthetized dog model, where all compounds were infused directly into the arterysupplying the gastric corpus. Secretin at an infusion rate of 10 ng/kg/min resulted in similar to 90% inhibition of gastric secretion in response to pentagastrin (20 ng/kg/min), whereas at the physiological postprandial concentration of 40 pg/ml it inhibited gastric secretion bysimilar to 55%, Gastric acid stimulated by gastrin I at the physiological post-prandial concentration of 150 pg/ml was inhibited by secretin at 40 pg/ml by similar to 80%. Pentagastrin stimulated histamine release to a peak of 168 +/- 34 ng/min, which was inhibited to 14 +/- 8 ng/min with the high concentration of secretin;nd to 85 +/- 21 ng/min at 40 pg/ml secretin. Gastrin I (150 pg/ml) stimulated histamine release to a peak of 10.6 +/- 4.6 ng/min, which was inhibited to 2.1 +/- 0.5ng/min by secretin (40 pg/ml). Because secretin has been reported to stimulate gastric somatostatin release, we examined the somatostatin secretory rate concomitant with histamine release. Both doses of secretin stimulated gastric somatostatin release, compared with pentagastrinalone. The present data demonstrate that secretin, even at physiological concentrations, can inhibit gastric acid secretion in response to gastrin/pentagastrin, and one of the mechanisms of inhibition involvesmodulation of gastric histamine release. This effect of secretin on histamine release may be either direct, at the histamine-containing endocrine cells, or indirect, through somatostatin release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:35:24