Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NAD(-DEPENDENT INTERNALIZATION OF THE TRANSMEMBRANE GLYCOPROTEIN CD38IN HUMAN NAMALWA B-CELLS())
Autore:
ZOCCHI E; FRANCO L; GUIDA L; PICCINI D; TACCHETTI C; DEFLORA A;
Indirizzi:
UNIV GENOA,INST BIOCHEM,VIALE BENEDETTO 17 I-16132 GENOA ITALY UNIV GENOA,INST BIOCHEM I-16132 GENOA ITALY UNIV GENOA,ADV BIOTECHNOL CTR I-16132 GENOA ITALY UNIV GENOA,INST ANAT I-16132 GENOA ITALY
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 396, anno: 1996,
pagine: 327 - 332
SICI:
0014-5793(1996)396:2-3<327:NIOTTG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC ADP-RIBOSE; HUMAN ERYTHROCYTES; ANTIGEN CD38; RECEPTOR DIMERIZATION; SELF-AGGREGATION; CYCLASE ACTIVITY; OUTER SURFACE; HYDROLYSIS; GLYCOHYDROLASE; ECTOENZYME;
Keywords:
CD38; NAD(+); GSH; ADP-RIBOSYL CYCLASE; ENDOCYTOSIS; ECTOENZYME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E. Zocchi et al., "NAD(-DEPENDENT INTERNALIZATION OF THE TRANSMEMBRANE GLYCOPROTEIN CD38IN HUMAN NAMALWA B-CELLS())", FEBS letters, 396(2-3), 1996, pp. 327-332

Abstract

CD38 is a transmembrane glycoprotein involved as an orphan receptor in many physiological processes of lymphocytes. It is also a bifunctional enzyme that catalyzes at its ectocellular domain the synthesis fromNAD(+) (cyclase) and the hydrolysis (hydrolase) of the calcium-mobilizing metabolite cyclic ADP-ribose (cADPR), A still unexplained paradoxconcerns the relationship between ectocellular localization of CD38 and intracellular calcium-releasing activity of its intermediate product cADPR, Incubation of CD38(+) human Namalwa B cells with external NAD(+) elicited extensive membrane down-regulation of CD38 and its internalization in non-clathrin-coated vesicles, Since the internalized CD38was demonstrated to be enzymatically active, this NAD(+)-dependent process is a hitherto unrecognized means for shifting cADPR metabolism from the cell surface to the intracellular environment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 01:33:43