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Titolo:
6-HYDROXYCATECHOLINE, A CHOLINE-MIMICKING ANALOG OF THE SELECTIVE NEUROTOXIN, 6-HYDROXYDOPAMINE
Autore:
SHEN R; TILLEKERATNE LMV; KIRCHHOFF JR; HUDSON RA;
Indirizzi:
UNIV TOLEDO,COLL PHARM,DEPT MED & BIOL CHEM TOLEDO OH 43606 UNIV TOLEDO,COLL PHARM,DEPT MED & BIOL CHEM TOLEDO OH 43606 UNIV TOLEDO,COLL ARTS & SCI,DEPT CHEM TOLEDO OH 43606
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 228, anno: 1996,
pagine: 187 - 192
SICI:
0006-291X(1996)228:1<187:6ACAOT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR; CATECHOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
R. Shen et al., "6-HYDROXYCATECHOLINE, A CHOLINE-MIMICKING ANALOG OF THE SELECTIVE NEUROTOXIN, 6-HYDROXYDOPAMINE", Biochemical and biophysical research communications, 228(1), 1996, pp. 187-192

Abstract

The synthesis and properties of 6-hydroxy-N,N-dimethylepinephrine (6-hpdroxy-catecholine) are reported. This agent is intended for use as aselective presynaptic cholinotoxin and is based on previously reported neurotoxins of the same type. 6-hydroxycatecholine is a close structural analogue of the catecholaminergic neurotoxin 6-hydroxydopamine, and is expected both to be selectively reactive at cholinergic sites and to undergo less vigorous and potentially more selective inactivatingreactions. It is also possible that in specific dementia-inducing pathologies, 6-hydroxycatecholine could be formed endogenously. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:41:09