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Titolo:
PACKED-COLUMN SUPERCRITICAL-FLUID CHROMATOGRAPHY OF A NEW DIHYDROPYRIDINE DRUG BASED ON DIRECT-INJECTION OF EMULSION SAMPLES
Autore:
KARLSSON L; GYLLENHAAL O; KARLSSON A; GOTTFRIES J;
Indirizzi:
ASTRA HASSLE AB,ANALYT CHEM S-43183 MOLNDAL SWEDEN
Titolo Testata:
Journal of chromatography
fascicolo: 1-2, volume: 749, anno: 1996,
pagine: 193 - 199
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOBILE-PHASE; LIQUID-CHROMATOGRAPHY; PEAK COMPRESSION; SEPARATION; SYSTEMS; HPLC;
Keywords:
DIRECT INJECTION; INJECTION METHODS; EMULSION SAMPLES; PHARMACEUTICAL ANALYSIS; EXPERIMENTAL DESIGN; CENTRAL COMPOSITE DESIGN; DIHYDROPYRIDINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
L. Karlsson et al., "PACKED-COLUMN SUPERCRITICAL-FLUID CHROMATOGRAPHY OF A NEW DIHYDROPYRIDINE DRUG BASED ON DIRECT-INJECTION OF EMULSION SAMPLES", Journal of chromatography, 749(1-2), 1996, pp. 193-199

Abstract

In this paper, a method based on direct injection in packed-column supercritical fluid chromatography (SFC) for the determination of a dihydropyridine drug in emulsion samples is described. To optimize the chromatographic system, an experimental design approach with four factorswas applied. The parameters studied were modifier-carbon dioxide ratio, flow-rate, column temperature and back-pressure. A face-centred central composite design (CCF) yielded a model with good fit and high predictive power. Using plates per second as the response parameter, a fast method for quantitative determination of the analyte was developed. Within the experimental space investigated, the concentration of the polar component in the mobile phase and the flow-rate were found to bethe important parameters. Peak compression effects, resulting in highapparent peak numbers (>80 000 versus a nominal value of 7000) were encountered when emulsion samples were injected.

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Documento generato il 30/09/20 alle ore 23:56:39