Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ADENOSINE A(2)-RECEPTOR MEDIATES ETHANOL-INDUCED ARTERIOLAR DILATION IN RAT STOMACH
Autore:
NAGATA H; SEKIZUKA E; MORISHITA T; TATEMICHI M; KUROKAWA T; MIZUKI A; ISHII H;
Indirizzi:
SAISEIKAI CENT HOSP,DEPT INTERNAL MED,MINATO KU,1-4-17 MITA TOKYO 108JAPAN NATL SAITAMA HOSP,INST CLIN RES WAKO SAITAMA 351 JAPAN SHIZUOKA RED CROSS HOSP,DEPT INTERNAL MED SHIZUOKA 420 JAPAN KEIO UNIV,SCH MED,DEPT INTERNAL MED TOKYO 160 JAPAN
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 6, volume: 34, anno: 1996,
pagine: 1028 - 1033
SICI:
0193-1857(1996)34:6<1028:AAMEAD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS NITRIC-OXIDE; GENE-RELATED PEPTIDE; PORTAL BLOOD-FLOW; INDUCED INCREASE; EXTRACELLULAR ADENOSINE; GASTRIC ARTERIOLES; MUCOSAL; METABOLISM; RECEPTORS; VENULES;
Keywords:
GASTRIC MICROCIRCULATION; IN VIVO MICROSCOPY; ETHANOL METABOLISM; ALCOHOL DEHYDROGENASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H. Nagata et al., "ADENOSINE A(2)-RECEPTOR MEDIATES ETHANOL-INDUCED ARTERIOLAR DILATION IN RAT STOMACH", American journal of physiology: Gastrointestinal and liver physiology, 34(6), 1996, pp. 1028-1033

Abstract

Topical application of ethanol to the gastrointestinal mucosa inducesvasodilation. Using an in vivo microscopy technique, we studied the effect of topical ethanol on the submucosal microvessels that control mucosal blood flow in the rat stomach and identified vasoactive substances and receptors that mediate the ethanol vasoaction. Topical ethanol(1-20%) dilated submucosal arterioles dose dependently, but did not change venular diameters. An inhibitor of alcohol dehydrogenase, 1 mM 4-methylpyrazole, did not alter the ethanol vasoaction. Ethanol-inducedarteriolar dilation was eliminated by adenosine deaminase, but other vasodilator inhibitors such as atropine, pyrilamine. indomethacin, human calcitonin gene-related peptide-(8-37), and N-omega-nitro-L-arginine methyl ester did not prevent it. Ethanol-induced arteriolar dilationwas inhibited by an adenosine A(2)-receptor antagonist, but not by anA(1)-receptor antagonist, whereas an A(2)-agonist, but not an A(1)-agonist, dose dependently dilated arterioles. Exogenous adenosine (10(-5)-10(-3) M) dilated arterioles to a similar extent as ethanol. This response was inhibited by an A(2)-antagonist. We conclude that nonmetabolized ethanol increases gastric mucosal blood flow via A(2)-receptors in submucosal arterioles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:15:40