Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RELATIONSHIPS OF DEHYDROEPIANDROSTERONE-SULFATE IN THE ELDERLY WITH FUNCTIONAL, PSYCHOLOGICAL, AND MENTAL STATUS, AND SHORT-TERM MORTALITY - A FRENCH COMMUNITY-BASED STUDY
Autore:
BERR C; LAFONT S; DEBUIRE B; DARTIGUES JF; BAULIEU EE;
Indirizzi:
HOP LA PITIE SALPETRIERE,INSERM U360 F-75651 PARIS 13 FRANCE UNIV BORDEAUX 2,INSERM U330 F-33076 BORDEAUX FRANCE HOP PAUL BROUSSE,SERV BIOCHIM F-94808 VILLEJUIF FRANCE HOP BICETRE,INSERM U33 F-94276 LE KREMLIN BICETR FRANCE
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 23, volume: 93, anno: 1996,
pagine: 13410 - 13415
SICI:
0027-8424(1996)93:23<13410:RODITE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; DEHYDROISOANDROSTERONE SULFATE; POSTMENOPAUSAL WOMEN; RANCHO-BERNARDO; SEX-DIFFERENCES; SERUM LEVELS; AGE; POPULATION; DEMENTIA; ADULTHOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
C. Berr et al., "RELATIONSHIPS OF DEHYDROEPIANDROSTERONE-SULFATE IN THE ELDERLY WITH FUNCTIONAL, PSYCHOLOGICAL, AND MENTAL STATUS, AND SHORT-TERM MORTALITY - A FRENCH COMMUNITY-BASED STUDY", Proceedings of the National Academy of Sciences of the United Statesof America, 93(23), 1996, pp. 13410-13415

Abstract

In human beings of both sexes, dehydroepiandrosterone sulfate (DHEAS)circulating in blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar range and 30-50% higher in men than in women) decreases with age, toward approximate to 20-10% of its value in young adults during the 8th and 9th decades. The mechanism of action of DHEA and DHEAS is poorly known and may include partial transformation into sex steroids, increase of bioavailable insulin-like growth factor I, and effects on neurotransmitter receptors. Whether thereis a cause-to-effect relationship between the decreasing levels of DHEAS with age and physiological and pathological manifestations of aging is still undecided, but this is of obvious theoretical and practicalinterest in view of the easy restoration by DHEAS administration. Here we report on 622 subjects over 65 years of age, studied for the 4 years since DHEAS baseline values had been obtained, in the frame of thePAQUID program, analyzing the functional, psychological, and mental status of a community-based population in the south-west of France. We confirm the continuing decrease of DHEAS serum concentration with age,more in men than in women, even if men retain higher levels. Significantly lower values of baseline DHEAS were recorded in women in cases of functional limitation (Instrumental Activities of Daily Living), confinement, dyspnea, depressive symptomatology, poor subjective perception of health and life satisfaction, and usage of various medications. In men, there was a trend for the same correlations, even though not statistically significant in most categories. No differences in DHEAS levels were found in cases of incident dementia in the following 4 years. In men (but not in women), lower DHEAS was significantly associatedwith increased short-term mortality at 2 and 4 years after baseline measurement. These results, statistically established by taking into account corrections for age, sex, and health indicators, suggest the need for further careful trials of the administration of replacement doses of DHEA in aging humans. Indeed, the first noted results of such ''treatment'' are consistent with correlations observed here between functional and psychological status and endogenous steroid serum concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 03:29:34