Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SIGNAL-TRANSDUCTION THROUGH HOMOLOGS OF THE STE20P AND STE7P PROTEIN-KINASES CAN TRIGGER HYPHAL FORMATION IN THE PATHOGENIC FUNGUS CANDIDA-ALBICANS
Autore:
LEBERER E; HARCUS D; BROADBENT ID; CLARK KL; DIGNARD D; ZIEGELBAUER K; SCHMIDT A; GOW NAR; BROWN AJP; THOMAS DY;
Indirizzi:
NATL RES COUNCIL CANADA,BIOTECHNOL RES INST,EUKARYOT GENET GRP,6100 ROYALMOUNT AVE MONTREAL PQ H4P 2R2 CANADA UNIV ABERDEEN,MARISCHAL COLL,DEPT MOL & CELL BIOL ABERDEEN AB9 1AS SCOTLAND BAYER AG,INST ANTIINFECT RES D-42096 WUPPERTAL GERMANY
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 23, volume: 93, anno: 1996,
pagine: 13217 - 13222
SICI:
0027-8424(1996)93:23<13217:STHOTS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE; FILAMENTOUS GROWTH; YEAST; ELEMENTS; SERINE; CDC42P; GENE; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
E. Leberer et al., "SIGNAL-TRANSDUCTION THROUGH HOMOLOGS OF THE STE20P AND STE7P PROTEIN-KINASES CAN TRIGGER HYPHAL FORMATION IN THE PATHOGENIC FUNGUS CANDIDA-ALBICANS", Proceedings of the National Academy of Sciences of the United Statesof America, 93(23), 1996, pp. 13217-13222

Abstract

The CST20 gene of Candida albicans was cloned by functional complementation of a deletion of the STE20 gene in Saccharomyces cerevisiae. CST20 encodes a homolog of the Ste20p/p65(PAK) family of protein kinases. Colonies of C. albicans cells deleted for CST20 revealed defects in the lateral formation of mycelia on synthetic solid ''Spider'' media. However, hyphal development was not impaired in some other media. A similar phenotype was caused by deletion of HST7, encoding a functional homolog of the S. cerevisiae Ste7p protein kinase. Overexpression of HST7 partially complemented the deletion of CST20. Cells deleted for CST20 were less virulent in a mouse model for systemic candidiasis. Our results suggest that more than one signaling pathway can trigger hyphal development in C. albicans, one of which has a protein kinase cascade that is analogous to the mating response pathway in S. cerevisiae and might have become adapted to the control of mycelial formation in asexual C. albicans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:59:16