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Titolo:
TRANSCRIPTIONAL REPRESSION BY YY1 IS MEDIATED BY INTERACTION WITH A MAMMALIAN HOMOLOG OF THE YEAST GLOBAL REGULATOR RPD3
Autore:
YANG WM; INOUYE C; ZENG YY; BEARSS D; SETO E;
Indirizzi:
UNIV S FLORIDA,H LEE MOFFIT CANC CTR & RES INST TAMPA FL 33612 UNIV S FLORIDA,H LEE MOFFIT CANC CTR & RES INST TAMPA FL 33612 UNIV TEXAS,HLTH SCI CTR,INST BIOTECHNOL,CTR MOL MED SAN ANTONIO TX 78245
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 23, volume: 93, anno: 1996,
pagine: 12845 - 12850
SICI:
0027-8424(1996)93:23<12845:TRBYIM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOVIRUS E1A PROTEIN; CO-REPRESSOR; SACCHAROMYCES-CEREVISIAE; ACTIVATION; BINDS; RECEPTORS; RELIEF; MYC; EXPRESSION; EUKARYOTES;
Keywords:
TRANSCRIPTION FACTOR; COREPRESSOR; PROTEIN-PROTEIN INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
W.M. Yang et al., "TRANSCRIPTIONAL REPRESSION BY YY1 IS MEDIATED BY INTERACTION WITH A MAMMALIAN HOMOLOG OF THE YEAST GLOBAL REGULATOR RPD3", Proceedings of the National Academy of Sciences of the United Statesof America, 93(23), 1996, pp. 12845-12850

Abstract

YY1 is a mammalian zinc-finger transcription factor with unusual structural and functional features. It has been implicated as a positive and a negative regulatory factor that binds to the CCATNTT consensus DNA element located in promoters of many cellular and viral genes. A mammalian cDNA that encodes a YY1-binding protein and possesses sequence homology with the yeast transcriptional factor RPD3 has been identified. A Ga14 DNA binding domain-mammalian RPD3 fusion protein strongly represses transcription from a promoter containing Ga14 binding sites. Association between YY1 and mammalian RPD3 requires a glycine-rich region on YY1. Mutations in this region abolish the interaction with mammalian RPD3 and eliminate transcriptional repression by YY1. These data suggest that YY1 negatively regulates transcription by tethering RPD3 to DNA as a cofactor and that this transcriptional mechanism is highlyconserved from yeast to human.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:11:14