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Titolo:
EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF RAMIPRIL ON THE DRINKING RESPONSE CAUSED BY INJECTION OF NORADRENALINE INTO THE 3RD VENTRICLE
Autore:
BARROS VM; SAAD WA; CAMARGO LAA; RENZI A; SAAD WA; MENANI JV;
Indirizzi:
UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14901903 ARARAQUARA SP BRAZIL UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14901903 ARARAQUARA SP BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 11, volume: 29, anno: 1996,
pagine: 1503 - 1505
SICI:
0100-879X(1996)29:11<1503:EOIIOR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; WATER-INTAKE; INHIBITION; CLONIDINE; RATS;
Keywords:
WATER INGESTION; CONVERTING-ENZYME INHIBITOR; NORADRENALINE; RAMIPRIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
V.M. Barros et al., "EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF RAMIPRIL ON THE DRINKING RESPONSE CAUSED BY INJECTION OF NORADRENALINE INTO THE 3RD VENTRICLE", Brazilian journal of medical and biological research, 29(11), 1996, pp. 1503-1505

Abstract

We studied the effect of ramipril injected into the third ventricle (3rdV) on the control of water intake induced by injection of noradrenaline into the 3rdV of adult male Holtzman rats (250-300 g) implanted with a chronic stainless steel cannula into the 3rdV. The injection volume was always 1 mu l and was injected over a period of 30-60 sec. Control animals were injected with 0.15 M NaCl. After the injection of isotonic saline (control, 0.15 M NaCl) into the 3rdV, water ingestion was 0.3 +/- 0.1 ml/h. Ramipril (1 mu g/mu l) injected into the 3rdV prior to isotonic saline produced no changes in water ingestion (0.4 +/- 0.2 ml/h). The injection of noradrenaline (40 nmol/mu l) after isotonicsaline induced an increase in water intake (3.0 +/- 1.1 ml/h). The prior injection of ramipril decreased this ingestion to 1.8 +/- 0.3 ml/h. These data show that the inhibition of converting enzyme in the brain reduces the water intake induced by catecholaminergic stimulation. We conclude that the brain is able to transform the prodrug ramipril into the active drug ramiprilat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:35:02